Different noses for different people
Different noses for different people
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DOI：
10.1038/ng1160
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发表时间：
2003-06-01
期刊：
影响因子：
30.8
通讯作者：
Gilad, Y
中科院分区：
文献类型：
--
作者：
Menashe, I;Man, O;Gilad, Y
在1000多个人类嗅觉受体基因中，超过一半似乎是假基因。我们通过对189个不同种族的人类的51个候选基因进行基因分型，研究了最近的这些干扰是否仍然与完整的形式分离。结果显示，分离假基因的现象前所未有地普遍存在，这是人类基因组中最显著的功能群体多样性案例之一。
Of more than 1,000 human olfactory receptor genes, more than half seem to be pseudogenes. We investigated whether the most recent of these disruptions might still segregate with the intact form by genotyping 51 candidate genes in 189 ethnically diverse humans. The results show an unprecedented prevalence of segregating pseudogenes, identifying one of the most pronounced cases of functional population diversity in the human genome.