A randomized, controlled pilot study of positive affect treatment adapted for anorexia nervosa.
A randomized, controlled pilot study of positive affect treatment adapted for anorexia nervosa.
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一项适用于神经性厌食症的积极情感治疗的随机对照试点研究。
DOI：
10.1002/eat.24071
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Peterson,CarolB
中科院分区：
文献类型：
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作者：
Haynos,AnnF;Anderson,LisaM;Askew,AutumnJ;Liu,Chassidie;Venables,Kira;Craske,MichelleG;Peterson,CarolB
目的成人神经性厌食症(AN)急需新的治疗方法。虽然已经开发出针对AN的心理干预措施，但没有一种被确定为优于另一种或非特异性治疗。常见的合并症(例如，情绪和焦虑症)很少针对治疗，可能会损害长期的临床改善。积极情感疗法是一种以神经科学为基础的行为疗法，是一种针对情感障碍的行为疗法。患有AN的成年人(N= 20)被随机分为20 周的PAT-AN或等待名单，以调查PAT-AN的可行性、可接受性、初步疗效和目标参与度(关于奖励机制)。结果PAT-AN表现出很强的保留率(100%)和可接受性评分(M= 5.67-5.95，满分为7分)。体重指数(p= .006)和进食障碍症状(p<； .001)在PAT-AN治疗期间有所改善。PAT-AN组在治疗前后体重指数、进食障碍症状和损害、抑郁和焦虑症状以及一些奖励指数(DS= .56-.87)方面出现了中等到很大的改善；这些变化在3个月的随访中基本保持不变。等待名单显示几乎所有指标的变化都可以忽略不计(DS<； .20)。讨论PAT-AN有望成为一种创新的治疗方法，能够同时改善进食障碍症状、情感症状和潜在的奖励机制。由于样本量较小，且允许同时参加其他治疗，因此应谨慎解释研究结果。这项研究对神经性厌食症(PAT-AN)的积极情感治疗(PAT-AN)进行了初步评估，PAT-AN是一种新颖的、神经科学知情的治疗方法，旨在增加一个人饮食障碍以外的有益生活经历。初步结果表明，帕特安被认为是可以接受的，可以缓解进食障碍、抑郁和焦虑症状。因此，这项研究提出了一种有希望的数据，这种治疗方法可能有可能改善这种疾病患者的生活。
ObjectiveNovel treatments for adults with anorexia nervosa (AN) are sorely needed. Although psychological interventions have been developed for AN, none have been identified as superior to one another or nonspecific treatments. Common comorbidities (e.g., mood and anxiety disorders) are rarely targeted in AN treatments, possibly impairing long‐term clinical improvement. AN is associated with reward processing dysfunctions paralleling those identified in affective disorders; however, few treatments directly target these processes.MethodWe adapted Positive Affect Treatment, a neuroscience‐informed behavioral treatment developed for affective disorders, to the treatment of AN (PAT‐AN). Adults with AN (N= 20) were randomized to 20 weeks of PAT‐AN or waitlist to investigate the feasibility, acceptability, preliminary efficacy, and target engagement (on reward mechanisms) of PAT‐AN.ResultsPAT‐AN demonstrated strong retention (100%) and acceptability ratings (M= 5.67–5.95 on a 7‐point scale). BMI (p= .006) and eating disorder symptoms (p< .001) improved over PAT‐AN sessions. The PAT‐AN group showed medium to large pre‐to‐post‐treatment improvements in BMI, eating disorder symptoms and impairment, depressive and anxiety symptoms, and some reward indices (ds= .56–.87); changes were largely sustained at 3‐month follow‐up. Waitlist showed negligible changes (ds< .20) on nearly all measures.DiscussionPAT‐AN holds promise as an innovative treatment with capability to simultaneously improve eating disorder symptoms, affective symptoms, and underlying reward mechanisms. Findings should be interpreted cautiously due to small sample size and permitted concurrent enrollment in other treatments. Future, larger‐scale research is warranted to establish the efficacy of PAT‐AN.Public SignificanceThis study provided a preliminary evaluation of Positive Affect Treatment for anorexia nervosa (PAT‐AN), a novel, neuroscience‐informed treatment aimed at increasing rewarding life experiences outside of one's eating disorder. Initial results suggest that PAT‐AN is considered acceptable and may alleviate eating disorder, depressive, and anxiety symptoms. Therefore, this study presents promising data on a treatment that may hold potential for improving the lives of individuals with this disorder.