Self-regulatory cognition and immune reactivity: idiographic success and failure feedback effects on the natural killer cell.
Self-regulatory cognition and immune reactivity: idiographic success and failure feedback effects on the natural killer cell.
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自我调节认知和免疫反应性：具体的成功和失败反馈对自然杀伤细胞的影响。
DOI：
10.1016/j.bbi.2004.01.003
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Coe,ChristopherL
中科院分区：
文献类型：
--
作者：
Strauman,TimothyJ;Woods,TeresaE;Schneider,KristinL;Kwapil,Lori;Coe,ChristopherL
诱导抑郁和焦虑的人写下他们的个人目标会降低自然杀伤细胞（NK）的活性，揭示了一种心理生物学途径，失败的经历会影响健康（）。然而，目前还不清楚类似的影响是否也发生在非痛苦的个体中。本研究采用相同的写作任务，在三种情况下（包括一个控制条件），通过启动自我和谐或自我差异来考察呈现具体的成功和失败反馈的急性生理效应。在每次书写后采集血样以测定NK活性，并计数循环中淋巴细胞的数量和类型以帮助解释细胞溶解性变化。两个自我相关的启动条件与免疫力的显着变化，和高自我差异的参与者更敏感。自我一致（成功）和自我不一致（失败）启动诱导情绪的显着变化，部分介导的免疫改变，但没有完全解释。如果随着时间的推移重复和持续，自我矛盾和自我和谐的偶然激活可以解释免疫反应的个体差异。
Inducing depressed and anxious individuals to write about their personal goals decreases natural killer (NK) cell activity, revealing a psychobiological pathway whereby experiences of failure can influence health (). However, it is unclear whether similar effects also occur in non-distressed individuals. This study used the same writing task to examine the acute physiological effects of presenting idiographic success and failure feedback by priming self-congruencies or self-discrepancies on three occasions (including a control condition). Blood samples were collected after each writing session to determine NK activity, and the number and type of lymphocytes in circulation were enumerated to help explain the cytolytic changes. The two self-relevant priming conditions were associated with significant alterations in immunity, and the high self-discrepant participants were more responsive. Both self-congruent (success) and self-discrepant (failure) priming induced significant shifts in mood, which partially mediated immune alterations but did not account for them completely. If repeated and sustained over time, incidental activation of self-discrepancies and self-congruencies could account for individual variation in immune responses.