Novel substance P antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P.
Novel substance P antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P.
复制标题
新型 P 物质拮抗剂 CP-96,345 可阻断猫脊髓背角神经元对有害皮肤刺激和 P 物质的反应。
DOI：
10.1016/0304-3940(91)90428-v
复制
发表时间：
1991
影响因子：
2.5
通讯作者：
Henry,JL
中科院分区：
文献类型：
--
作者：
Radhakrishnan,V;Henry,JL
Responses of dorsal horn neurons to iontophoretic application of substance P (80–120 nA), and to noxious thermal and noxious mechanical stimulations of the receptive field in the hind limb were tested in adult cats before and after the administration of the specific, non-peptide, NK-1 receptor antagonist CP-96,345 (0.5 mg/kg, i.v.). CP-96,345 inhibited the response of the neurones to substance P and also the response of these substance P-sensitive neurones to noxious thermal stimulation. The response of the substance P-insensitive neurones to noxious heat stimulations were, however, unaffected by CP-96,345. The effect of CP-96,345 on the response of neurones to noxious mechanical stimulation was variable. The results confirm the role of substance P in thermal nociception.
