Glucoprivation induces anestrus and lipoprivation may induce hibernation in Syrian hamsters.
Glucoprivation induces anestrus and lipoprivation may induce hibernation in Syrian hamsters.
复制标题
叙利亚仓鼠的葡萄糖缺乏会导致不发情，而脂肪缺乏可能会导致冬眠。
DOI：
10.1152/ajpregu.1993.264.3.r573
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
G. Wade
中科院分区：
文献类型：
--
作者：
J. E. Schneider;D. G. Friedenson;A. J. Hall;G. Wade
先前的结果支持这样的观点，即叙利亚仓鼠的发情周期对代谢燃料的总体可用性有反应，而不是对脂肪酸或葡萄糖本身的可用性有反应。为了验证这一想法，我们对仓鼠的发情周期进行了监测，这些仓鼠被随意喂养并接受了一定剂量的2-脱氧-d -葡萄糖（2-DG），一种葡萄糖利用抑制剂。2-DG在750 ~ 1250 mg/kg剂量范围内处理的仓鼠表现出正常的发情周期，但较高剂量（1750或2000 mg/kg）会引起停情。虽然从这些数据可以清楚地看出，发情周期受到葡萄糖活化的影响，但尚不清楚它们是否对脂肪酸可用性降低有反应。各组仓鼠自由进食，并给予一定剂量的棕榈酸甲酯（MP），一种脂肪酸利用抑制剂。一些接受最高剂量的仓鼠变得迟钝，因此没有进行前凸测试。接受过mp治疗的恒温仓鼠没有一只出现昏厥。其他的实验检验了禁食仓鼠体内葡萄糖的作用。体脂含量高的仓鼠可避免禁食引起的早泄。相比之下，被低剂量2-DG （750 mg/kg）处理的脂肪食物剥夺的仓鼠出现了昏厥。因此，当葡萄糖利用被阻断时，从脂肪组织中动员的脂肪酸并不能预防禁食引起的早泄。一种解释是，在禁食期间，脂肪酸的利用为参与控制发情周期的其他组织节省了葡萄糖。（摘要删节250字）
Previous results supported the notion that estrous cycles in Syrian hamsters are responsive to the general availability of metabolic fuels, rather than to either fatty acid or glucose availability per se. To test this idea, we monitored estrous cycles in hamsters that were fed ad libitum and treated with a range of doses of 2-deoxy-D-glucose (2-DG), an inhibitor of glucose utilization. Hamsters treated with 2-DG at doses ranging from 750-1,250 mg/kg showed normal estrous cycles, but higher doses (1,750 or 2,000 mg/kg) induced anestrus. While it is clear from these data that estrous cycles are affected by glucoprivation, it is not clear whether they are responsive to decreased fatty acid availability. Groups of hamsters were fed ad libitum and treated with a range of doses of methyl palmoxirate (MP), an inhibitor of fatty acid utilization. Some of the hamsters that received the highest doses became torpid and thus were not tested for lordosis. None of the euthermic, MP-treated hamsters became anestrous. Other experiments examined the role of glucose availability in fasted hamsters. Hamsters with a high body fat content were protected from fasting-induced anestrus. In contrast, fat food-deprived hamsters treated with low doses of 2-DG (750 mg/kg) became anestrous. Thus fatty acids mobilized from adipose tissue did not prevent fasting-induced anestrus when glucose utilization was blocked. One interpretation is that during fasting fatty acid utilization spares glucose for other tissues involved in the control of estrous cycles.(ABSTRACT TRUNCATED AT 250 WORDS)