Dynamical response of nanomechanical oscillators in immiscible viscous fluid for in vitro biomolecular recognition
Dynamical response of nanomechanical oscillators in immiscible viscous fluid for in vitro biomolecular recognition
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DOI：
10.1103/physrevlett.96.186105
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发表时间：
2006-05-12
影响因子：
8.6
通讯作者：
Mohanty, P
中科院分区：
文献类型：
--
作者：
Dorignac, J;Kalinowski, A;Mohanty, P
浸入粘性流体中的纳米机械悬臂梁结构的动态响应对于体外单分子力谱、疾病特异性蛋白质的生物分子识别以及微观蛋白质动力学研究非常重要。在这里，我们研究了生物功能化纳米机械悬臂梁在粘性流体中的随机响应。利用涨落耗散定理，我们推导出位移谱密度的精确表达式和共振频移的线性近似。我们发现，在一个粘性的解决方案中的纳米级悬臂梁的频率偏移是由表面应力所产生的生物分子相互作用与质量负载由于生物分子的贡献可以忽略不计。
Dynamical response of nanomechanical cantilever structures immersed in a viscous fluid is important to in vitro single-molecule force spectroscopy, biomolecular recognition of disease-specific proteins, and the study of microscopic protein dynamics. Here we study the stochastic response of biofunctionalized nanomechanical cantilever beams in a viscous fluid. Using the fluctuation-dissipation theorem we derive an exact expression for the spectral density of displacement and a linear approximation for resonance frequency shift. We find that in a viscous solution the frequency shift of the nanoscale cantilever is determined by surface stress generated by biomolecular interaction with negligible contributions from mass loading due to the biomolecules.