Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure
Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure
复制标题
DOI：
10.1161/circresaha.114.303915
复制
发表时间：
2014-05-09
影响因子：
20.1
通讯作者：
Thum, Thomas
中科院分区：
文献类型：
--
作者：
Kumarswamy, Regalla;Bauters, Christophe;Thum, Thomas
原理：长链非编码RNA代表了一类新的调节基因表达的分子。长链非编码RNA存在于体液中，但其作为生物标志物的潜力从未在心血管疾病中研究过。Objective：To study role of long noncoding RNAs as potential biomarkers in heart diseases.Methods and Results：Global transcriptomic analyses were done in plasma RNA from patients with or without left ventricular remodeling after myocardial infarction.在发生心脏重塑和心力衰竭的3个独立患者队列（788例患者）中验证了受管制的候选药物。线粒体长非编码RNA uc022bqs.1（LIPCAR）在心肌梗死后早期下调，但在后期上调。LIPCAR水平确定患者发展心脏重塑和独立的其他风险标志物与未来的心血管deaths.Conclusions：LIPCAR是一种新的心脏重塑的生物标志物，并预测未来的死亡心力衰竭患者。
Rationale: Long noncoding RNAs represent a novel class of molecules regulating gene expression. Long noncoding RNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease.Objective: To study the role of long noncoding RNAs as potential biomarkers in heart disease.Methods and Results: Global transcriptomic analyses were done in plasma RNA from patients with or without left ventricular remodeling after myocardial infarction. Regulated candidates were validated in 3 independent patient cohorts developing cardiac remodeling and heart failure (788 patients). The mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages. LIPCAR levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths.Conclusions: LIPCAR is a novel biomarker of cardiac remodeling and predicts future death in patients with heart failure.