Real-time influenza surveillance in Germany -: Results of a pilot project
Real-time influenza surveillance in Germany -: Results of a pilot project
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DOI：
10.1007/s00430-002-0133-2
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发表时间：
2002-12-01
影响因子：
5.4
通讯作者：
Schöttler, M
中科院分区：
文献类型：
--
作者：
Lange, W;Schöttler, M
实时监测信息是准确诊断流感的先决条件，然后使用神经氨酸酶抑制剂对急性流感进行适当治疗。通过REALFLU（TM）监测，霍夫曼-罗氏公司开发了一个国际流感早期预警系统。对德国新开发的实时流感监测系统进行可行性检验，并与德国流感研究组（Arbeitsgemeinschaft Influenza，AGI）建立的流感哨点系统进行比较。1999/ 2000年和2000/2001年冬季对REALFLU（TM）监测进行了评价。由报告医生看到的患者中流感样疾病的百分比和罗氏甲型/B流感快速检测试剂盒的阳性结果每天通过互联网报告，进行评估，并可在动态互联网网页上实时调用。项目参与者小组可以随时在有密码保护的互联网网页上调用对当前数据的评价。通过与AGI获得的数据进行回顾性比较，表明两个系统之间具有良好的一致性。在与国家参考中心（NRZ）的病毒分离株比较时，获得了更好的一致性。这证实了所选方法的可靠性。REALFLU（TM）监测提供的流感爆发信息比NRZ和AGI早1-2周。结果表明，对流感进行实时监测是可能的，也是合理的。在REALFLU（TM）监测的总体范围内，德国的试点项目能够在两个冬季实时和区域化地反映流感情况。罗氏甲型/B流感快速检测被证明是一种有用的监测工具。
Real-time surveillance information is the prerequisite for accurate influenza diagnosis followed by appropriate treatment of acute influenza with neuraminidase inhibitors. With REALFLU(TM) Surveillance, Hoffmann-La Roche has developed an international early warning system for influenza. The feasibility of the newly developed real-time influenza surveillance in Germany was tested and the results were compared with those of the established German influenza sentinel system of Influenza Study Group (Arbeitsgemeinschaft Influenza, AGI). The evaluation of the REALFLU(TM) Surveillance was performed during the winters of 1999/ 2000 and 2000/2001. The percentage of influenza-like illnesses among patients seen by the reporting physicians and positives of the Roche Influenza A/B Rapid Test were reported daily by internet, evaluated and could be called up on dynamic internet web pages real-time. The group of project participants could at any time call up the evaluations of the current data on password-protected internet web pages. A retrospective comparison with data obtained by the AGI showed good agreement between the two systems. Even better agreement was obtained on comparing the data with the virus isolates of the National Reference Centers (NRZ). This confirms the reliability of the selected methodology. REALFLU(TM) Surveillance provided information about influenza outbreaks 1-2 weeks earlier than NRZ and the AGI. The results show that it is possible and reasonable to conduct influenza surveillance on a real-time basis. In an overall context of REALFLU(TM) Surveillance, the German pilot project was capable of reflecting the influenza situation on a real-time and regionalized basis during both winters. The Roche Influenza A/B Rapid test proved to be a useful surveillance tool.