Impact of Comorbidities on Lung Cancer Screening Evaluation.
Impact of Comorbidities on Lung Cancer Screening Evaluation.
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合并症对肺癌筛查评估的影响。
DOI：
10.1016/j.cllc.2022.03.012
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发表时间：
2022
影响因子：
3.6
通讯作者：
Kale,MinalS
中科院分区：
文献类型：
--
作者：
Robinson,EricM;Liu,BenjaminY;Sigel,Keith;Yin,Chung;Wisnivesky,Juan;Kale,MinalS
目的：我们使用前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验的数据来研究自我报告的慢性阻塞性肺疾病、冠状动脉疾病、中风和糖尿病对肺癌筛查评估中诊断并发症的影响。在我们的分析中，我们纳入了来自常规护理和干预的个体，（年度胸部X线），年龄等于或大于55岁，有20包年吸烟史，接受过侵入性手术。我们进行了多变量logistic回归分析，以估计合并症与手术并发症的关系。我们的主要结果是严重或中度并发症的发生率。与高危并发症相关的特征包括年龄较大（OR = 1.03/年，P= .001），冠状动脉疾病史（OR = 1.40，P = .03），糖尿病史（OR = 0.41，P < .001），目前吸烟状况（OR = 1.46，P ≤ .001），手术活检（OR = 7.39，P <0.001）、穿刺活检（OR = 1.94，P <0.001）、其他侵入性操作（OR = 1.58，P <0.001）。未发现与并发症、脑卒中史（OR = 0.84，P = 0.53）或慢性阻塞性肺疾病史（OR = 1.27，P = 0.06）相关的肺癌筛查。因此，有关个体风险因素和高风险并发症的数据应纳入诊断算法，以优化临床获益并最大限度地减少伤害。需要对本文确定的风险因素进行进一步研究和验证。
Objectives: We used data from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial to examine the impact of self-reported chronic obstructive pulmonary disease, coronary artery disease, stroke, and diabetes mellitus on diagnostic complications in lung cancer screening evaluation.Methods: In our analysis, we included individuals from the usual care and intervention (annual chest x-ray) of the lung cancer screening trial with equal or greater than 55 years of age with a 20 pack-year smoking history who had undergone an invasive procedure. We performed multivariate logistic regression analysis to estimate the association of comorbidity on procedure complication. Our primary outcome was the incidence of major or moderate complications.Results: Features associated with high-risk complication included older age (OR = 1.03 per year,P= .001), history of coronary artery disease (OR = 1.40,P= .03), history of diabetes mellitus (OR = 0.41,P< .001, current smoking status (OR = 1.46,P≤ .001), surgical biopsy (OR = 7.39,P< .001), needle biopsy (OR = 1.94,P< .001), and other invasive procedure (OR = 1.58,P< .001). We did not find an associated with complication and history of stroke (OR = 0.84,P= .53) or chronic obstructive pulmonary disease (OR = 1.27,P= .06).Conclusion: Patient and procedure-level factors may alter the benefits of lung cancer screening. Data concerning individual risk factors and high-risk complications should therefore be incorporated into diagnostic algorithms to optimize clinical benefit and minimize harm. Further study and validation of the risk factors identified herein are warranted.
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荷兰-比利时随机肺癌筛查试验中肺部手术后的并发症。
DOI：
10.1093/ejcts/ezs081
发表时间：
2012
期刊：
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
影响因子：
--
作者：
S. V. van't Westeinde;N. Horeweg;P. De Leyn;H. Groen;J. Lammers;C. Weenink;K. Nackaerts;R. V. van Klaveren
通讯作者：
R. V. van Klaveren
影响因子：
5.3
作者：
Janssen-Heijnen, MLG;Schipper, RM;Coebergh, JWW
通讯作者：
Coebergh, JWW
影响因子：
5
作者：
Hiraki, Takao;Mimura, Hidefumi;Kanazawa, Susumu
通讯作者：
Kanazawa, Susumu
影响因子：
4.8
作者：
Heyer, Christoph M.;Reichelt, Stefanie;Nicolas, Volkmar
通讯作者：
Nicolas, Volkmar
疑似肺癌活检原则：靶向治疗时代仍以侵袭为主？
影响因子：
2.5
作者：
Hua;Jin;Chongrui Xu;Y. Lei;D. Luo;Hong;Yi
通讯作者：
Yi