Is advanced age associated with increased incidence and severity of chemotherapy-induced peripheral neuropathy?
Is advanced age associated with increased incidence and severity of chemotherapy-induced peripheral neuropathy?
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DOI：
10.1007/s00520-005-0868-6
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发表时间：
2006-03-01
影响因子：
3.1
通讯作者：
Chroni, E
中科院分区：
文献类型：
--
作者：
Argyriou, AA;Polychronopoulos, P;Chroni, E
目的：当前的情况检验了这样的假设：高龄与化疗引起的周围神经病变（CIPN）的发病率和严重程度增加密切相关。患者和方法：我们前瞻性研究了 35 名接受紫杉醇或顺铂为基础的肺癌或乳腺癌治疗方案的癌症患者。所有患者在基线、第三个、第六个化疗疗程以及化疗停止后 3 个月内均接受了详细的临床和电生理学评估，以筛查 CIPN。修改后的周围神经病变（PNP）评分的平均值总结了临床和电生理学研究的结果。结果：根据年龄将患者分为两组（平均年龄差，p=0.000），即年龄小于 65 岁的患者（组 I，n=18）和年龄大于或等于 65 岁的组（组 II，n=17）。根据每位患者的临床、神经学和电生理学变量，确定 CIPN 的发生率和严重程度，然后进行组间比较。 I 组（9/18 例患者，50%）和 II 组（8/17 例患者，52.9%）之间的神经毒性发生率相似（p=0.869）。同样，根据平均 PNP 评分，不同年龄组的 CIPN 严重程度相似 (p=0.897)。电生理学数据的年龄组间比较显示，所检查的任何运动或感觉传导参数都没有显着差异。结论：我们的研究表明，老年癌症患者发生 CIPN 的风险并不较高，而高龄与 CIPN 最严重程度无关。
Purpose: The current setting tested the hypothesis that advanced age would be strongly associated with increased incidence and severity of chemotherapy-induced peripheral neuropathy (CIPN). Patients and methods: We prospectively studied 35 cancer patients treated with paclitaxel or cisplatin-based regimens for lung or breast cancer. All patients underwent a detailed clinical and electrophysiological evaluation for screening of CIPN at baseline, at the third, the sixth course of chemotherapy and up to 3 months after its cessation. Means of a modified Peripheral Neuropathy (PNP) score summarized the results of the clinical and electrophysiological study. Results: Patients were divided according to their age in two groups (mean age difference, p=0.000) to those younger than 65 years (group I, n=18) and those older or equal than 65 years (group II, n=17). According to the clinical, neurological and electrophysiological variables of each patient, the incidence and severity of CIPN was determined and then compared between groups. The incidence of neurotoxicity was similar (p=0.869) between group I (9/18 patients, 50%) and group II (8/17 patients, 52.9%). Likewise, according to the mean PNP scores, the severity of CIPN was similar between age groups (p=0.897). The between-age-groups comparison of electrophysiological data revealed no significant differences in any of the motor or sensory conduction parameters examined. Conclusion: Our study indicates that elderly cancer patients do not have greater risk of CIPN, whilst advanced age was not associated with worst severity of CIPN.