Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: Implication for assessment of disease activity and treatment
Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: Implication for assessment of disease activity and treatment
复制标题
DOI：
10.1016/j.jneuroim.2008.05.006
复制
发表时间：
2008-08-13
影响因子：
3.3
通讯作者：
Ballerini, Clara
中科院分区：
文献类型：
--
作者：
Mazzanti, Benedetta;Aldinucci, Alessandra;Ballerini, Clara
已提出MSC作为MS的可能治疗：在这项研究中，从10名MS患者和6名健康供体（HD）获得的MSC在表型和功能特征方面进行了比较。我们表明，从MS和HD中分离的MSC对于IPIO的产生显著不同。因此，尽管从MS患者中分离的MSC在增殖、表型、体外分化、TLR表达、免疫抑制能力、抑制DC分化和活化方面表现出与HD MSC相同的性质，但自体MSC在自身免疫性疾病的细胞治疗中的应用应提交仔细的评估和治疗。(C)2008由爱思唯尔公司出版
MSCs have been proposed as possible treatment in MS: In this Study MSCs obtained from 10 MS patients and 6 healthy donors (HD) were compared in terms of phenotypical and functional characteristics. We show that MSCs isolated from MS and HD differ significantly for IPIO production. Therefore, although MSCs isolated from MS patients exhibit the same properties of HD MSCs in terms of proliferation, phenotype, in vitro differentiation, TLR expression, immunosuppressive ability, inhibition of DC differentiation and activation, the use of autologous MSCs in cell therapy of autoimmune diseases Should be submitted to attentive evaluation and treatment. (C) 2008 Published by Elsevier B.V.