Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis.
Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis.
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DOI：
10.14740/jocmr2545w
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Sugiyama M
中科院分区：
文献类型：
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作者：
Shigeishi H;Sugiyama M
口腔人乳头瘤病毒（HPV）感染与口腔癌的发生有关。然而，很少有流行病学调查集中在健康个体的口腔HPV流行率。本研究的目的是提供关于全球无口腔癌患者口腔HPV患病率的最新信息。我们系统地回顾了29项报告口腔HPV感染患病率的研究，其中包括22，756名受试者（10，124名男性，12，623名女性和9名性别未知;年龄范围2 - 89岁），并于2012年1月至2015年6月发表。报告病例中总HPV、低危型HPV、高危型HPV和HPV 16的患病率分别为5.5%、2.2%、2.7%和1.0%。与异性恋男性（4.7%）和女性（2.9%）相比，与男性发生性关系的男性（12.2%）的总体HPV患病率明显较高。进行荟萃分析以阐明口腔HPV感染的重要危险因素，其显示口交和吸烟与口腔HPV感染有显著的统计学关联（OR：1.90，95% CI：1.51 ~ 2.39，P < 0.0001; OR：2.13，95% CI：1.32 ~ 3.43，P = 0.002）。我们的研究结果表明，性行为和吸烟与健康个体的口腔HPV感染有重要关系。
Oral human papillomavirus (HPV) infection is associated with oral cancer development. However, few epidemiologic investigations have focused on oral HPV prevalence in healthy individuals. The objective of this study was to provide updated information regarding oral HPV prevalence in patients without oral cancer worldwide. We systematically reviewed 29 studies reporting the prevalence of oral HPV infection that included 22,756 subjects (10,124 males, 12,623 females, and nine unknown gender; age range 2 - 89 years) and were published from January 2012 to June 2015. The prevalence of overall HPV, low-risk type HPV, high-risk type HPV, and HPV16 in the reported cases was 5.5%, 2.2%, 2.7%, and 1.0%, respectively. The prevalence of overall HPV was considerably higher in males who had sex with males (12.2%) as compared to heterosexual males (4.7%) and females (2.9%). A meta-analysis was performed to elucidate significant risk factors for oral HPV infection, which revealed a significant statistical association for oral sex and smoking with oral HPV infection (odds ratio (OR): 1.90, 95% confidence interval (CI): 1.51 - 2.39, P < 0.0001; OR: 2.13, 95% CI: 1.32 - 3.43, P = 0.002). Our findings suggest that sexual behavior and smoking are importantly related to oral HPV infection in healthy individuals.