NIR fluorescent small molecules for intraoperative imaging.
NIR fluorescent small molecules for intraoperative imaging.
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DOI：
10.1002/wnan.1337
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Choi HS
中科院分区：
文献类型：
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作者：
Owens EA;Lee S;Choi J;Henary M;Choi HS
生物成像和纳米医学的最新进展使分子光学成像在图像引导手术中的应用成为可能；然而，影响造影剂最佳性能的参数尚未精确确定。为了开发理想的图像引导手术造影剂，我们需要考虑以下标准：1)近红外窗口的激发和发射波长，2)优化光学特性以获得高体内性能，3)克服或利用生物分布和清除，4)减少非特异性摄取。设计考虑应集中在优化光学和物理化学性质的标准。生物分布和清除应该首先考虑，因为它们介导了造影剂在体内的命运，例如静脉注射造影剂后达到峰值信号与背景比（SBR）的时间和信号持续的时间（保留）。
Recent advances in bioimaging and nanomedicine have permitted the exploitation of molecular optical imaging in image-guided surgery; however, the parameters mediating optimum performance of contrast agents are not yet precisely determined. To develop ideal contrast agents for image-guided surgery, we need to consider the following criteria: 1) excitation and emission wavelengths in the NIR window, 2) optimized optical characteristics for high in vivo performance, 3) overcoming or harnessing biodistribution and clearance, and 4) reducing nonspecific uptake. The design considerations should be focused on optimizing the optical and physicochemical property criteria. Biodistribution and clearance should first be considered because they mediate the fate of a contrast agent in the body such as how long after intravenous injection a contrast agent reaches the peak signal-to-background ratio (SBR) and how long the signal lasts (retention).