The functions of antigen recognition in T cell-dependent B cell activation.
The functions of antigen recognition in T cell-dependent B cell activation.
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DOI：
10.1006/smim.1993.1047
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发表时间：
1993-12-01
影响因子：
7.8
通讯作者：
Parker, D C
中科院分区：
文献类型：
--
作者：
Parker, D C
B细胞通过充当抗原特异性APC从T细胞获得帮助。来自B细胞抗原受体的信号对于有效的抗原呈递或对于B细胞对T细胞帮助的应答是不需要的。T细胞通过制造淋巴因子来提供帮助，其中一些淋巴因子，如CD40配体，保持与T细胞相关并需要细胞接触才能发挥作用。II类MHC的功能是在T细胞中诱导帮助，而不是将帮助传递给B细胞。T细胞辅助使用与B细胞抗原受体参与的细胞内信号传导途径不同的细胞内信号传导途径。
B cells get help from T cells by acting as antigen-specific APC. A signal from the B cell antigen receptor is not required for efficient antigen presentation or for the B cell response to T cell help. T cells provide help by making lymphokines, some of which, like CD40 ligand, remain T cell-associated and require cell contact for function. The function of class II MHC is to induce help in the T cell, rather than to deliver help to the B cell. T cell help uses different intracellular signaling pathways from those engaged by the B cell antigen receptor.