Association of Genetic Variants With Moyamoya Disease in 13 000 Individuals A Meta-Analysis
Association of Genetic Variants With Moyamoya Disease in 13 000 Individuals A Meta-Analysis
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DOI：
10.1161/strokeaha.120.029527
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发表时间：
2020-06-01
期刊：
影响因子：
8.3
通讯作者：
Liu, Wanyang
中科院分区：
文献类型：
--
作者：
Wang, Xiaotong;Wang, Yue;Liu, Wanyang
背景和目的-越来越多的证据表明，遗传因素在烟雾病（MMD）中起着关键作用。由于样本量小和缺乏可复制的结果，对这种疾病的研究得出的结论一直受到阻碍。本荟萃分析旨在确定这些基因多态性是否与MMD.Methods-PubMed、Google Scholar、Embase、Wanfang、Web of Science和China National Knowledge Infrastructure数据库中的MMD.Methods-PubMed、Google Scholar和Wanfang数据库中的MMD. Methods-Pub使用Review Manager 5.2和Stata 15.0软件程序进行统计分析。异源性使用Cochran Q检验进行评估，并使用I-2 test. Results-4711例MMD病例和8704例对照纳入24项研究，评估6个基因的7个多态性。MMP-2 rs 243865等位基因模型的固定效应比值比（95%CI）为0.60（0.41-0.88）（P=0.008）。在基于国家的亚组分析中，在等位基因模型中，RNF 213 rs 112735431的固定效应比值比（95%CI）为中国，39.74（26.63-59.31），日本，74.65（42.79-130.24）和韩国，50.04（28.83-86.88;所有P
Background and Purpose-A growing body of evidence indicates genetic components play critical roles in moyamoya disease (MMD). Firm conclusions from studies of this disease have been stymied by small sample sizes and a lack of replicative results. This meta-analysis was conducted to determine whether these genetic polymorphisms are associated with MMD.Methods-PubMed, Google Scholar, Embase, Wanfang, Web of Science, and China National Knowledge Infrastructure databases were used to identify potentially relevant studies published until January 2020. The Review Manager 5.2 and Stata 15.0 software programs were used to perform the statistical analysis. Heterogeneity was assessed using the Cochran Q test and quantified using the I-2 test.Results-Four thousand seven hundred eleven MMD cases and 8704 controls in 24 studies were included, evaluating 7 polymorphisms in 6 genes. The fixed-effect odds ratios (95% CI) in allelic model of MMP-2 rs243865 were 0.60 (0.41-0.88) (P=0.008). In the country-based subgroup analysis, the fixed-effect odds ratios (95% CI) of RNF213 rs112735431 in allelic model were China, 39.74 (26.63-59.31), Japan, 74.65 (42.79-130.24) and Korea, 50.04 (28.83-86.88; all P