THE ORIGIN OF PROTEINURIA AT HIGH-ALTITUDE
THE ORIGIN OF PROTEINURIA AT HIGH-ALTITUDE
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DOI：
10.1136/pgmj.63.737.179
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发表时间：
1987-03-01
影响因子：
5.1
通讯作者：
JONES, GT
中科院分区：
文献类型：
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作者：
WINTERBORN, MH;BRADWELL, AR;JONES, GT
本文对14名正常人在海拔4846米高原适应4-6天后静脉输注赖氨酸前后的尿蛋白排泄量进行了测定。尿白蛋白排泄前赖氨酸升高11名受试者，但α 1-微球蛋白检测到只有四个。赖氨酸后，所有受试者的白蛋白排泄量均大幅增加。再加上赖氨酸之前没有α 1-微球蛋白，这意味着肾小球毛细血管通透性增加是适应高海拔后蛋白尿的主要原因。估计的最低肾小球液白蛋白浓度增加2至3倍以上的正常对照发表的值。
Urinary protein excretion was measureed before and after the intravenous infusion of lysine in 14 normal subjects after 4-6 days'' acclimatization at 4846 m. Urinary albumin excretion before lysine was elevated in 11 subjects but alpha1-microglobulin was detected in only four. After lysine a large increase in albumin excretion occurred in all subjects. Together with the absence of alpha1-microglobulin before lysine this implies that increased glomerular capillary permeability is the major cause of proteinuria after acclimatization to high altitude. The estimated minimum glomerular fluid albumin concentration was increased two to three-fold above the published values in normal controls.