MODELING THE INFLUENCE OF RISK-FACTORS ON FAMILIAL AGGREGATION OF DISEASE
MODELING THE INFLUENCE OF RISK-FACTORS ON FAMILIAL AGGREGATION OF DISEASE
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DOI：
10.2307/2532650
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发表时间：
1991-09-01
期刊：
影响因子：
1.9
通讯作者：
AALEN, OO
中科院分区：
文献类型：
--
作者：
AALEN, OO
人们经常观察到疾病危险因素的家族相似性。于是就产生了下面的问题：由于这种相似性，预计疾病病例的家族聚集性有多大？这个问题是通过一个特定的模型，其中的风险应该是指数依赖于风险因素。只有对亲属（父亲/儿子）被考虑。计算是用正态分布的风险因子和特定的偏态分布进行的。应用于冠心病。
One often observes a familial resemblance of risk factors of disease. The following question then arises: How much familial aggregation of cases of disease would be expected because of this resemblance? This problem is attacked through a particular model where the risk is supposed to depend exponentially on the risk factors. Only pairs of relatives (father/son) are considered. The calculations are performed both with normally distributed risk factors and with particular skewed distributions. An application to coronary heart disease is given.