Patterns of postictal cerebral perfusion in idiopathic generalized epilepsy: a multi-delay multi-parametric arterial spin labelling perfusion MRI study.
Patterns of postictal cerebral perfusion in idiopathic generalized epilepsy: a multi-delay multi-parametric arterial spin labelling perfusion MRI study.
复制标题
特发性全身性癫痫发作后脑灌注模式：多延迟多参数动脉自旋标记灌注 MRI 研究
DOI：
10.1038/srep28867
复制
发表时间：
2016-07-04
影响因子：
4.6
通讯作者：
Gong Q
中科院分区：
文献类型：
--
作者：
Chen G;Lei D;Ren J;Zuo P;Suo X;Wang DJ;Wang M;Zhou D;Gong Q
特发性全身性癫痫（IGE）的脑血流动力学状态是一个非常复杂的过程。动脉自旋标记（ASL）灌注磁共振成像（MRI）检测IGE时脑血流（CBF）的变化很少受到关注。然而，单延迟ASL的最佳延迟时间的选择是困难的。多延迟多参数ASL灌注MRI克服了单延迟ASL的局限性。我们应用多延迟多参数ASL灌注MRI研究IGE失神发作患者的发作后脑灌注模式。共纳入21例IGE失神发作患者和24例健康对照受试者。IGE患者左侧上级颞回的动脉通过时间（ATT）延长。IGE患者左侧颞中回、左侧海马旁回和左侧梭状回的平均脑血流量明显增加。IGE患者左侧上级颞回ATT延长与发病年龄呈负相关。这项研究表明，颞叶和梭状回的皮质功能障碍可能与IGE患者失神发作的癫痫活动有关。这些信息可以发挥重要作用，阐明IGE的病理生理机制，从脑血流动力学的角度。
The cerebral haemodynamic status of idiopathic generalized epilepsy (IGE) is a very complicated process. Little attention has been paid to cerebral blood flow (CBF) alterations in IGE detected by arterial spin labelling (ASL) perfusion magnetic resonance imaging (MRI). However, the selection of an optimal delay time is difficult for single-delay ASL. Multi-delay multi-parametric ASL perfusion MRI overcomes the limitations of single-delay ASL. We applied multi-delay multi-parametric ASL perfusion MRI to investigate the patterns of postictal cerebral perfusion in IGE patients with absence seizures. A total of 21 IGE patients with absence seizures and 24 healthy control subjects were enrolled. IGE patients exhibited prolonged arterial transit time (ATT) in the left superior temporal gyrus. The mean CBF of IGE patients was significantly increased in the left middle temporal gyrus, left parahippocampal gyrus and left fusiform gyrus. Prolonged ATT in the left superior temporal gyrus was negatively correlated with the age at onset in IGE patients. This study demonstrated that cortical dysfunction in the temporal lobe and fusiform gyrus may be related to epileptic activity in IGE patients with absence seizures. This information can play an important role in elucidating the pathophysiological mechanism of IGE from a cerebral haemodynamic perspective.