TAM receptor signaling in development
TAM receptor signaling in development
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DOI：
10.1387/ijdb.160285tb
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发表时间：
2017-01-01
影响因子：
0.7
通讯作者：
Burstyn-Cohen, Tal
中科院分区：
文献类型：
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作者：
Burstyn-Cohen, Tal
Tyro3、Ax1和MERTK是家族的受体蛋白酪氨酸激酶。在其配体S(Pros1)和生长停滞特异性6(Gas6)的激活下，它们在整个发育和成年期调节着许多细胞功能。它们由多种细胞类型和组织表达，参与免疫、神经、血管、骨骼和生殖系统的动态平衡调节。信号在成人组织中的功能丧失最终导致组织稳态的破坏和疾病状态的破坏，而在各种肿瘤中的功能获得促进了癌症的表型。配体-受体的组合作用可能会引起不同的分子和细胞反应。的许多调节功能本质上是发育的，发生在胚胎发育期间和出生后。本文就受体及其配体在免疫、神经、血管和生殖系统发育过程中的作用作一综述。
TYRO3, AXL and MERTK comprise the TAM family of receptor protein tyrosine kinases. Activated by their ligands, protein S (PROS1) and growth-arrest-specific 6 (GAS6), they mediate numerous cellular functions throughout development and adulthood. Expressed by a myriad of cell types and tissues, they have been implicated in homeostatic regulation of the immune, nervous, vascular, bone and reproductive systems. The loss-of-function of TAM signaling in adult tissues culminates in the destruction of tissue homeostasis and diseased states, while TAM gain-of-function in various tumors promotes cancer phenotypes. Combinatorial ligand-receptor interactions may elicit different molecular and cellular responses. Many of the TAM regulatory functions are essentially developmental, taking place both during embryogenesis and postnatally. This review highlights current knowledge on the role of TAM receptors and their ligands during these developmental processes in the immune, nervous, vascular and reproductive systems.