Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications.
Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications.
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DOI：
10.3389/fmolb.2022.864286
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发表时间：
2022
影响因子：
5
通讯作者：
中科院分区：
文献类型：
--
作者：
Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Structurally, there are two types of five-membered triazoles: 1,2,3-triazole and 1,2,4-triazole. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities. These are also important in organocatalysis, agrochemicals, and materials science. Thus, they have a broad range of therapeutic applications with ever-widening future scope across scientific disciplines. However, adverse events such as hepatotoxicity and hormonal problems lead to a careful revision of the azole family to obtain higher efficacy with minimum side effects. This review focuses on the structural features, synthesis, and notable therapeutic applications of triazoles and related compounds.
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DOI：
10.1039/p29890001903
发表时间：
1989-11-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
影响因子：
--
作者：
ALBERT, A;TAYLOR, PJ
通讯作者：
TAYLOR, PJ
影响因子：
2.1
作者：
Dhavale, DD;Matin, MM
通讯作者：
Matin, MM
影响因子：
3.2
作者：
Faria-Ramos, Isabel;Tavares, Pedro R.;Rodrigues, Acacio G.
通讯作者：
Rodrigues, Acacio G.
影响因子：
4.1
作者：
HITCHCOCK, CA;DICKINSON, K;ADAMS, DJ
通讯作者：
ADAMS, DJ
影响因子：
4.1
作者：
Aneja B;Azam M;Alam S;Perwez A;Maguire R;Yadava U;Kavanagh K;Daniliuc CG;Rizvi MMA;Haq QMR;Abid M
通讯作者：
Abid M