Secretin as a neurohypophysial factor regulating body water homeostasis
Secretin as a neurohypophysial factor regulating body water homeostasis
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DOI：
10.1073/pnas.0903695106
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发表时间：
2009-09-15
影响因子：
11.1
通讯作者：
Chow, Billy K. C.
中科院分区：
文献类型：
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作者：
Chu, Jessica Y. S.;Lee, Leo T. O.;Chow, Billy K. C.
下丘脑大细胞神经元表达神经垂体激素、加压素或催产素之一，沿着不同的神经肽或神经调质。这些神经元的轴突终末通常被认为只释放这两种激素，而不释放其他激素进入循环。在这里，我们表明，胰泌素，最初从上肠粘膜提取物中分离出来，存在于整个下丘脑-神经垂体轴，它是从垂体后叶血浆高渗条件下释放。在下丘脑，它刺激血管加压素的表达和释放。考虑到这些发现与我们以前的研究结果，显示了一个直接的影响，促胰液素对肾脏的水重吸收，我们建议在这里，促胰液素在多个层次的工作在下丘脑，垂体和肾脏，以调节水的稳态。这里提出的研究结果挑战以前的理解，神经垂体，并可能提供新的概念，在治疗疾病相关的神经调节。
Hypothalamic magnocellular neurons express either one of the neurohypophysial hormones, vasopressin or oxytocin, along with different neuropeptides or neuromodulators. Axonal terminals of these neurons are generally accepted to release solely the two hormones but not others into the circulation. Here, we show that secretin, originally isolated from upper intestinal mucosal extract, is present throughout the hypothalamo-neurohypophysial axis and that it is released from the posterior pituitary under plasma hyperosmolality conditions. In the hypothalamus, it stimulates vasopressin expression and release. Considering these findings together with our previous findings that show a direct effect of secretin on renal water reabsorption, we propose here that secretin works at multiple levels in the hypothalamus, pituitary, and kidney to regulate water homeostasis. Findings presented here challenge previous understanding regarding the neurohypophysis and could provide new concepts in treating disorders related to osmoregulation.