Genome-wide patterns of gene flow across a house mouse hybrid zone
Genome-wide patterns of gene flow across a house mouse hybrid zone
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DOI：
10.1101/gr.6757907
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发表时间：
2008-01-01
期刊：
影响因子：
7
通讯作者：
Tucker, Priscilla K.
中科院分区：
文献类型：
--
作者：
Teeter, Katherine C.;Payseur, Bret A.;Tucker, Priscilla K.
近缘种或亚种间的杂交区为研究物种形成的遗传结构提供了有用的环境。使用分布在小鼠基因组中的标记，我们使用两种最近分化的家鼠（小家鼠和小家鼠）之间的杂交区作为自然作图实验，以确定可能参与生殖隔离的基因组区域。使用无性系分析，我们记录了近SO倍的标记之间的渐渗水平的变化。一些标记具有非常窄的渐变群宽度，这些基因组区域可能有助于生殖隔离。与这些狭窄的渐变群相关的生物过程包括对环境的生理和免疫反应以及生殖的生理和行为方面。其他常染色体标记表现出不对称的宽倾向，通常与高频率的M。在M.混合区的肌肉侧。这些标记识别基因组区域，这些区域可能包含从一个物种传播到另一个物种的等位基因。与这些广泛的渐变群相关的生物学过程包括细胞信号传导、嗅觉和信息素反应。这些过程在生存和繁殖中起着重要作用，相关基因可能是选择的目标。杂种区中心的连锁不平衡模式表明，隔离可能是由多组基因之间的多重上位性相互作用引起的。这些数据突出了物种形成的复杂遗传结构，甚至在分化的早期阶段，并指出了一些可能支配这种结构的生物过程。
Hybrid zones between closely related species or Subspecies provide useful settings for Studying the genetic architecture of speciation. Using markers distributed throughout the mouse genome, we use a hybrid Zone between two recently diverged species Of house mice (Mus musculus and Mus domesticus) as a natural mapping experiment to identify genomic regions that may be involved in reproductive isolation. Using cline analysis we document a nearly SO-fold variation in level of introgression among markers. Some markers have extremely narrow cline widths; these genomic regions may contribute to reproductive isolation. Biological processes associated with these narrow clines include physiological and immune responses to the environment as well as physiological and behavioral aspects of reproduction. Other autosomal markers exhibit asymmetrically broad clines, usually with high frequencies of M. domesticus alleles on the M. musculus side of the hybrid zone. These markers identify genome regions likely housing genes with alleles that are spreading from one species to the other. Biological processes associated with these wide clines include cell signaling, olfaction, and pheromone response. These processes play important roles in survival and reproduction, and associated genes are likely targets of selection. Patterns of linkage disequilibrium in the center of the hybrid zone Suggest that isolation may be caused by multiple epistatic interactions between sets of genes. These data highlight the complex genetic architecture underlying speciation even at early stages of divergence and point to some of the biological processes that may govern this architecture.