ESTROGEN RAPIDLY POTENTIATES AMPHETAMINE-INDUCED STRIATAL DOPAMINE RELEASE AND ROTATIONAL BEHAVIOR DURING MICRODIALYSIS
ESTROGEN RAPIDLY POTENTIATES AMPHETAMINE-INDUCED STRIATAL DOPAMINE RELEASE AND ROTATIONAL BEHAVIOR DURING MICRODIALYSIS
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DOI：
10.1016/0304-3940(90)90618-j
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发表时间：
1990-10-16
影响因子：
2.5
通讯作者：
BECKER, JB
中科院分区：
文献类型：
--
作者：
BECKER, JB
Ovariectomy (OVX) of female rats results in a decreased behavioral response to stimulation of the mesostriatal dopamine (DA) system and decreased striatal DA release in vitro. Estrogen replacement restores both behavioral and neurochemical responsiveness. In this report, microdialysis in freely moving rats is used to simultaneously study the behavioral and neurochemical effects of systemic estradiol. OVX rats received a unilateral 6-hydroxydopamine lesion of the substantia nigra and then underwent microdialysis of the intact striatum. Thirty min after a single injection of 5 .mu.g estradiol benzoate, amphetamine-induced rotational behaviour and striatal DA release are both potentiated, relative to the response of oil-treated control animals.
