Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study
Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study
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DOI：
10.1192/bjp.bp.111.092387
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发表时间：
2012-02-01
影响因子：
10.5
通讯作者：
O'Brien, John T.
中科院分区：
文献类型：
--
作者：
Colloby, Sean J.;Firbank, Michael J.;O'Brien, John T.
背景少数研究表明老年抑郁症患者脑血流量（CBF）的变化，但研究之间存在相当大的不一致性。目的采用动脉自旋标记（ASL）磁共振成像（MRI）研究老年抑郁症患者和年龄相仿的健康对照组的CBF变化。对30例健康人和38例抑郁症患者进行ASL和T1加权MRI扫描。对于每个人，单独的灰色和白色物质CBF的区域估计。组差异CBF及其与临床features.ResultsSignificant增加观察到白色物质CBF抑郁症患者相对于对照组（F-1.65=9.7，P=0.003）。两组间外侧额叶、内侧额叶、扣带回、中央和顶叶区域的灰质CBE无显著差异（F-1，F-65 = 0.2）。抑郁症患者的白色脑血流与蒙哥马利-艾斯伯格抑郁量表（MADRS）评分呈显著相关（r '=-0.42，P =0.03）。进一步的分析显示，与对照组相比，抑郁症缓解期的受试者的白色脑血流明显升高（n=21，MADRS = 11，P=0.80）。结论脑白质病变可能是脑白质的代偿性反应，成功的抗抑郁治疗（或预测），也许是通过促进特定回路中的神经传递，从而减少抑郁症状。
BackgroundA limited number of studies have demonstrated changes in cerebral blood flow (CBF) in older individuals with depression, but there are considerable inconsistencies between studies.AimsTo investigate changes in CBF using arterial spin labelling (ASL) magnetic resonance imaging (MRI) in people with late-life depression and in a similarly aged healthy control group.MethodSixty-eight participants (30 healthy individuals, 38 with depression) underwent ASL and T-1-weighted MRI scanning. For each individual, regional estimates of separate grey and white matter CBF were obtained. Group differences in CBF and their associations with clinical features were examined.ResultsSignificant increases were observed in white matter CBF in patients with depression relative to the control group (F-1.65=9.7, P=0.003). Grey matter CBE in lateral frontal, medial frontal, cingulate, central and parietal regions did not significantly differ between groups (F-1,F-65 = 0.2). A significant correlation was found between white matter CBF and Montgomery-Asberg Depression Rating Scale (MADRS) scores in depression (r'=-0.42, P=0.03). Further analyses revealed that compared with controls, significant elevation of white matter CBF was apparent in participants whose depression was in remission (n=21, MADRS = 11, P=0.80).ConclusionsFindings suggest a compensatory response to white matter pathological change or a response to (or a predictor of) successful antidepressant treatment, perhaps by facilitating neurotransmission in specific circuits and so reducing depressive symptoms.