Impact of A Six Week Training Program on Ventilatory Efficiency, Red Blood Cell Rheological Parameters and Red Blood Cell Nitric Oxide Signaling in Young Sickle Cell Anemia Patients: A Pilot Study
Impact of A Six Week Training Program on Ventilatory Efficiency, Red Blood Cell Rheological Parameters and Red Blood Cell Nitric Oxide Signaling in Young Sickle Cell Anemia Patients: A Pilot Study
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DOI：
10.3390/jcm8122155
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发表时间：
2019-12-01
影响因子：
3.9
通讯作者：
Connes, Philippe
中科院分区：
文献类型：
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作者：
Grau, Marijke;Nader, Elie;Connes, Philippe
镰状细胞性贫血（SCA）患者表现出受损的净化效率，改变血液流变学，高水平的氧化/亚硝化应激和增强的溶血与大量的循环游离血红蛋白，这降低了一氧化氮（NO）的生物利用度。这项研究的目的是调查体育锻炼是否可以改善这些生理和生物标志物描述有助于SCA的病理生理。12名SCA患者参加了一个为期6周的对照训练计划，训练量适中（每周两次，每次持续15-30分钟），强度为第一次训练阈值的70%。比较训练前（T0）和训练后（T1）的参数。在T0和T1结束后一年通过问卷调查检查日常活动。结果显示，在T1时，提高了排便效率，减少了亚硝化应激，降低了血浆游离血红蛋白浓度，增加了血浆亚硝酸盐水平，改变了流变学，而对运动性能参数或血液学特征没有观察到影响。红细胞（RBC）NO参数表明NO生物利用度增加，但不影响RBC变形性。参与者增加了日常生活活动水平。这项初步研究的数据得出结论，即使是低强度的活动也是可行的，可能对SCA患者的健康有益。
Patients with sickle cell anemia (SCA) show impaired ventilatory efficiency, altered blood rheology, high levels of oxidative/nitrosative stress and enhanced hemolysis with large amounts of circulating free hemoglobin, which reduces nitric oxide (NO) bioavailability. The aim of the study was to investigate whether physical exercise could improve these physiological and biological markers described to contribute to SCA pathophysiology. Twelve SCA patients participated in a controlled six weeks training program with moderate volume (two sessions per week with 15-30 min duration per session) and intensity (70% of the first ventilatory threshold). Parameters were compared before (T0) and after (T1) training. Daily activities were examined by a questionnaire at T0 and one year after the end of T1. Results revealed improved ventilatory efficiency, reduced nitrosative stress, reduced plasma free hemoglobin concentration, increased plasma nitrite levels and altered rheology at T1 while no effect was observed for exercise performance parameters or hematological profile. Red blood cell (RBC) NO parameters indicate increased NO bioavailability which did not affect RBC deformability. Participants increased their daily life activity level. The data from this pilot study concludes that even low intensity activities are feasible and could be beneficial for the health of SCA patients.