Protein expression of ATP-binding cassette transporters ABCC10 and ABCC11 associates with survival of colorectal cancer patients
Protein expression of ATP-binding cassette transporters ABCC10 and ABCC11 associates with survival of colorectal cancer patients
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DOI：
10.1007/s00280-016-3114-7
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发表时间：
2016-09-01
影响因子：
3
通讯作者：
Soucek, P.
中科院分区：
文献类型：
--
作者：
Krizkova, V.;Dubova, M.;Soucek, P.
本研究探讨了ATP结合盒（ABC）转运蛋白ABCC 10和ABCC 11蛋白表达在结直肠癌中的预后意义。在140例结直肠癌患者的肿瘤组织块中评估了ABCC 10和ABCC 11蛋白含量，并与5-氟尿嘧啶治疗患者的生存率相关。与高表达ABCC 10的肿瘤相比，肿瘤中低ABCC 10蛋白含量使患者死亡的风险比增加三倍以上（P = 0.004）。相比之下，低ABCC 11含量使患者癌症复发的风险比增加了近4倍（P = 0.016）。对接受基于5-氟尿嘧啶治疗方案的患者的分析显示，肿瘤中ABCC 11含量低的患者比含量高的患者的无病间隔时间短（P = 0.024）。本研究首次表明，ABCC 10的蛋白表达与总生存率显著相关，ABCC 11的表达与疾病相关。为进一步验证其在结直肠癌患者中的预后价值提供了强有力的推动力。
This study investigated the prognostic importance of protein expression of ATP-binding cassette (ABC) transporters ABCC10 and ABCC11 in colorectal cancer.Protein content of ABCC10 and ABCC11 was assessed in tumor tissue blocks of 140 colorectal cancer patients and associated with survival of patients with regard to 5-fluorouracil-based therapy.Low ABCC10 protein content in tumors increased hazard ratio of patient's death more than three times in comparison with high ABCC10-expressing tumors (P = 0.004). In contrast, the low ABCC11 content increased the hazard ratio of cancer recurrence in patients almost four times (P = 0.016). Analysis of patients treated with regimens based on 5-fluorouracil revealed that patients with low ABCC11 content in their tumors had shorter disease-free interval than those with higher content (P = 0.024).The present study shows for the first time that the protein expression of ABCC10 significantly associates with overall survival and the expression of ABCC11 with disease-free interval of colorectal cancer patients and provides strong impulse for further validation of their prognostic value in colorectal cancer.