On the release of metronidazole from natural rubber latex membranes
On the release of metronidazole from natural rubber latex membranes
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DOI：
10.1016/j.msec.2010.09.007
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发表时间：
2011-03-12
影响因子：
7.9
通讯作者：
Graeff, Carlos F. O.
中科院分区：
文献类型：
--
作者：
Herculano, Rondinelli D.;Alencar de Queiroz, Alvaro A.;Graeff, Carlos F. O.
如果开发出合适的包封程序，药物的受控释放可以是有效的，这需要生物相容性材料来保持和释放药物。在这项研究中，天然橡胶胶乳（NRL）膜用于提供甲硝唑（MET），一个强大的抗原虫剂。根据能量色散X射线光谱，发现MET被吸附在NRL膜上，很少或没有掺入膜本体中。X射线衍射和FTIR光谱数据表明，MET保留其结构和光谱特性后，封装在NRL膜，没有分子水平的相互作用，可以改变MET的抗菌活性。更重要的是，MET在NRL膜中的体外释放时间从口服片剂或注射剂的典型6-8小时增加到约20小时。100小时药物释放动力学可用双指数函数拟合，两个特征时间为3.6和29.9 h。这证明了已知由NRL膜提供的诱导的血管生成可以与药物的受控释放组合，其动力学可以通过修改用于特定应用的膜制造的实验条件来定制。(C)2010 Elsevier B. V.保留所有权利。
The controlled release of drugs can be efficient if a suitable encapsulation procedure is developed, which requires biocompatible materials to hold and release the drug. In this study, a natural rubber latex (NRL) membrane is used to deliver metronidazole (MET), a powerful antiprotozoal agent. MET was found to be adsorbed on the NRL membrane, with little or no incorporation into the membrane bulk, according to energy dispersive X-ray spectroscopy. X-ray diffraction and FTIR spectroscopy data indicated that MET retained its structural and spectroscopic properties upon encapsulation in the NRL membrane, with no molecular-level interaction that could alter the antibacterial activity of MET. More importantly, the release time of MET in a NRL membrane in vitro was increased from the typical 6-8 h for oral tablets or injections to ca. 100 h. The kinetics of the drug release could be fitted with a double exponential function, with two characteristic times of 3.6 and 29.9 h. This is a demonstration that the induced angiogenesis known to be provided by NRL membranes can be combined with a controlled release of drugs, whose kinetics can be tailored by modifying experimental conditions of membrane fabrication for specific applications. (C) 2010 Elsevier B.V. All rights reserved.