Non-Hodgkin's lymphoma in homosexual men in the San Francisco Bay Area: occupational, chemical, and environmental exposures.
Non-Hodgkin's lymphoma in homosexual men in the San Francisco Bay Area: occupational, chemical, and environmental exposures.
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旧金山湾区男同性恋者的非霍奇金淋巴瘤：职业、化学品和环境暴露。
DOI：
10.1097/00042560-199707010-00006
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Bracci,P
中科院分区：
文献类型：
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作者：
Holly,EA;Lele,C;Bracci,P
1988年至1995年间，在旧金山弗朗西斯科湾区进行了一项以人群为基础的病例对照研究，1593例符合条件的NHL受试者和2515例对照受试者均报告了化学、职业和其他暴露作为同性恋男性非霍奇金淋巴瘤（NHL）的危险因素。结果为312名男性同性恋NHL和420名同性恋对照组。艾滋病毒阳性患者不太可能比对照组的技术，销售和行政职业工作;服务职业;和精密生产，工艺，或修理相关的职业。他们可能较少接触石油产品、醛类、清洁溶剂、粘合剂、杀虫剂、焊接烟雾、焦油、沥青、烟灰或灰烬。HIV阴性患者不太可能比对照组的管理或专业的专业职业和技术工作。销售或行政职业。HIV阴性患者比对照组受试者更可能暴露于除草剂（OR= 2.0，CI= 0.89至4.7）、放射性（OR= 4.7，CI= 1.7至13）和焦油、烟灰、沥青或灰烬（250+小时：OR= 2.3，CI= 0.96至5.6）。HIV阴性的NHL患者也更有可能在儿童时期生活在农场比对照组（OR= 2.4，CI= 1.0至5.6）。合并艾滋病毒状态，患者更有可能作为机动车或铁路运营商超过1年（OR= 2.1，CI= 0.98至4.4）。大多数职业接触时间很短，据报告，许多化学品接触程度很低。没有发现明显和强烈的关联，尽管与暴露于几种化学物质相关的NHL风险在HIV阳性男性中普遍降低，而在HIV阴性男性中升高。
Chemical, occupational, and other exposures as risk factors for non-Hodgkin's lymphoma (NHL) among homosexual men are reported from a population-based case-control study of 1593 eligible subjects with NHL and 2515 control subjects conducted in the San Francisco Bay Area between 1988 and 1995. Results are presented for 312 homosexual men with NHL and 420 homosexual control subjects. HIV-positive patients were less likely than control subjects to have worked in technical, sales, and administrative occupations; service occupations; and precision production, craft, or repair-related occupations. They were likely to have had less exposure to petroleum products, aldehydes, cleaning solvents, adhesives, insecticides, welding fumes, and tar, pitch, soot, or ash. The HIV-negative patients were less likely than the control subjects to have worked in managerial or professional specialty occupations and in technical. sales, or administrative occupations. HIV-negative patients were somewhat more likely than control subjects to have been exposed to herbicides (OR= 2.0, CI= 0.89 to 4.7), to radioactivity (OR= 4.7, CI= 1.7 to 13), and to tar, soot, pitch, or ash (250+ hours: OR= 2.3, CI= 0.96 to 5.6). HIV-negative NHL patients also were somewhat more likely to have lived on a farm as children than the control subjects (OR= 2.4, CI= 1.0 to 5.6). Pooled over HIV status, patients were somewhat more likely to have worked as motor vehicle or rail operators for more than 1 year (OR= 2.1, CI= 0.98 to 4.4). Most occupational exposures were of brief duration and many chemical exposures were reported as minimal. No clear and strong associations were found, although the risk for NHL related to exposure to several chemicals generally was reduced among HIV-positive men and elevated among HIV-negative men.