Early capillary flux homogenization in response to neural activation
Early capillary flux homogenization in response to neural activation
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DOI：
10.1177/0271678x15605851
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发表时间：
2016-02-01
影响因子：
6.3
通讯作者：
Boas, David A.
中科院分区：
文献类型：
--
作者：
Lee, Jonghwan;Wu, Weicheng;Boas, David A.
这篇简短的通讯报道了大鼠大脑皮层体感激活过程中毛细血管网络流动的早期均质化。我们使用光学相干断层扫描和统计强度变化分析来几乎同时以 1 秒的分辨率追踪数百个毛细血管中红细胞通量的变化。我们观察到，虽然平均毛细管通量在激活过程中表现出典型的增加，但毛细管通量的标准偏差在平均通量增加之前表现出早期下降。该网络级数据与毛细管流动在激活过程中均匀化以改善氧气输送的理论假设一致。
This Brief Communication reports early homogenization of capillary network flow during somatosensory activation in the rat cerebral cortex. We used optical coherence tomography and statistical intensity variation analysis for tracing changes in the red blood cell flux over hundreds of capillaries nearly at the same time with 1-s resolution. We observed that while the mean capillary flux exhibited a typical increase during activation, the standard deviation of the capillary flux exhibited an early decrease that happened before the mean flux increase. This network-level data is consistent with the theoretical hypothesis that capillary flow homogenizes during activation to improve oxygen delivery.