Resorbable dicalcium phosphate bone substitutes prepared by 3D powder printing
Resorbable dicalcium phosphate bone substitutes prepared by 3D powder printing
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DOI：
10.1002/adfm.200700019
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发表时间：
2007-12-17
影响因子：
19
通讯作者：
Barralet, Jake E.
中科院分区：
文献类型：
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作者：
Gbureck, Uwe;Hoezel, Tanja;Barralet, Jake E.
在这项研究中，采用将 3D 粉末打印与磷酸钙水泥化学相结合的新型 3D 打印工艺，在室温下制造了具有编程结构的生物陶瓷骨替代物。在打印过程中，双相α/β-磷酸三钙（Ca-3(PO4)(2)，TCP）粉末与磷酸溶液组成的液体成分反应，形成二水磷酸二钙（CaHPO4中心点H2O，DCPD，透钙磷石）和未反应的TCP的基质。打印后，打印样品的抗压强度在 0.9-8.7 MPa 之间，具体取决于酸浓度。通过在磷酸中对样品进行三次一分钟的额外硬化洗涤，可以将强度进一步提高到最大 22 MPa。经过这种处理后，样品主要由透钙磷石和少量未反应的 TCP 组成，以及少量的无水磷酸二钙（CaHPO4、DCPA、三斜磷钙石）。透钙磷石水热转化为 DCPA 导致孔隙率增加约 13%，强度降低至 15 MPa，但肌内植入 56 周后证明体内吸收率增加。与常用的烧结技术相比，主要优点是加工温度低，这使得能够制造热不稳定且可降解的磷酸二钙基质。
Bioceramic bone substitutes with programmed architecture were manufactured at room temperature in this study using a novel 3D printing process that combined 3D powder printing with calcium phosphate cement chemistry. During printing, biphasic alpha/beta-tricalcium phosphate (Ca-3(PO4)(2), TCP) powder reacted with a liquid component consisting of phosphoric acid solution to form a matrix of dicalcium phosphate dihydrate (CaHPO4 center dot H2O, DCPD, brushite) and unreacted TCP. Printed samples showed compressive strengths between 0.9-8.7 MPa after printing depending on the acid concentration. A further strength improvement to a maximum of 22 MPa could be obtained by additional hardening of the samples in phosphoric acid for three one minute washes. After this treatment, the samples mainly consisted of brushite with minor phases of unreacted TCP and a lesser amount of dicalcium phosphate anhydrate (CaHPO4, DCPA, monetite). Hydrothermal conversion of brushite to DCPA resulted in an increase of porosity of approximately 13% and a decrease of strength to 15 MPa, however the resorption rate in vivo was increased as demonstrated after intramuscular implantation over 56 weeks. Major advantages compared with commonly used sintering techniques are the low processing temperature, which enables the fabrication of thermally instable and degradable matrices of secondary calcium phosphates.