The Effect of ELF Magnetic Field on Tumor Growth after Electrochemotherapy
The Effect of ELF Magnetic Field on Tumor Growth after Electrochemotherapy
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DOI：
10.1007/s00232-013-9605-0
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发表时间：
2013-11
期刊：
影响因子：
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通讯作者：
Akram Mahna;S. Firoozabadi;Zeinab Shankayi
中科院分区：
文献类型：
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作者：
Akram Mahna;S. Firoozabadi;Zeinab Shankayi
从根本上说，化疗是最广泛使用的癌症治疗方法，尽管它对正常细胞和组织有副作用。电化学治疗(ECT)是一种增加癌细胞对药物的渗透性，从而减少其剂量的方法。显然，它利用电脉冲在细胞膜上制造电孔。ECT可以缩小肿瘤体积；但这种作用不是永久性的，已有部分再生长的报道。这项研究的目的是研究磁场在预防ECT后肿瘤再生长方面的潜力。将荷瘤Balb/c小鼠暴露于磁场(15 mT，50 MHz)中12天，第一天加用70V/cm的电脉冲和博莱霉素。磁场可使肿瘤体积显著缩小，而电穿孔+电穿孔+电磁场组与电穿孔+电穿孔组之间无显著差异。外加磁场(15mT，50 MHz)可显著降低肿瘤生长速度，而对ECT效率无明显影响。
From a fundamental point of view, chemotherapy is the most widely used treatment for cancers despite its side effects on normal cells and tissues. Electrochemotherapy (ECT) is a method for increasing the permeability of cancer cells to drugs and, hence, decreasing their dosage. It apparently creates electropores on the cell membrane using electric pulses. ECT can decrease tumor volume; but this effect is not permanent, and partial regrowth has been reported. The aim of this study was to investigate the potential of magnetic fields in preventing the regrowth of tumors after ECT. Tumoral Balb/c mice were exposed to a magnetic field (15 mT, 50 Hz) for 12 days after treating additionally with 70 V/cm electric pulses and bleomycin at the first day. The magnetic field caused a significant reduction in tumor volumes, while there was no significant difference between the ECT and the electroporation with ECT and magnetic field groups. The exploited magnetic field (15 mT, 50 Hz) could decrease the tumor growth rate significantly, without any effect on ECT efficiency.