Inhibition of testicular luteinizing hormone receptor level by treatment with a potent luteinizing hormone-releasing hormone agonist of human chorionic gonadotropin.
Inhibition of testicular luteinizing hormone receptor level by treatment with a potent luteinizing hormone-releasing hormone agonist of human chorionic gonadotropin.
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用人绒毛膜促性腺激素的强效黄体生成素释放激素激动剂治疗，抑制睾丸黄体生成素受体水平。
DOI：
10.1016/0006-291x(77)91579-0
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发表时间：
1977
影响因子：
3.1
通讯作者：
A. Schally
中科院分区：
文献类型：
--
作者：
C. Auclair;P. Kelly;F. Labrie;D. Coy;A. Schally
用有效的促黄体激素释放激素激动剂[D-Leu6，Des-Gly-NH210]LHRH乙胺或人绒毛膜促性腺激素治疗成年雄性大鼠一周后，睾丸组织中的促黄体激素受体显著下降。这些治疗也显着降低了睾丸重量，而血浆睾酮水平在LHRH激动剂治疗后降低，在hCG治疗后升高。单次注射LHRH激动剂或人绒毛膜促性腺激素(HCG)也导致睾丸黄体生成素结合部位的长期丢失，受体水平在第8天恢复到控制值。这些发现表明，无论是单次注射还是重复注射一种有效的LHRH激动剂，内源性黄体生成素的升高都能够下调睾丸的黄体生成素受体，从而导致睾丸体积缩小和血浆睾酮浓度下降的长期效应。
Treatment of adult male rats with a potent luteinizing hormone-releasing hormone agonist, [D-Leu6, Des-Gly-NH210] LHRH ethylamide or human chorionic gonadotropin for one week caused a marked decline in luteinizing hormone receptors in testicular tissue. Testicular weight was also significantly decreased by these treatments while plasma testosterone levels were decreased by treatment with the LHRH agonist and increased after hCG. A single injection of the LHRH agonist or hCG also induced a long-lasting loss of testis LH binding sites with receptor levels returning to control values at 8 days. These findings indicate than an elevation of endogenous LH, whether induced by single or repeated injection of a potent LHRH agonist, is capable of down regulating testicular LH receptors with a resultant long-term effect of reduced testicular size and decreased plasma testosterone concentration.