Inhibition of acid secretion in dog by metiamide, a histamine antagonist acting on H2 receptors.
Inhibition of acid secretion in dog by metiamide, a histamine antagonist acting on H2 receptors.
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甲乙酰胺（一种作用于 H2 受体的组胺拮抗剂）可抑制狗的胃酸分泌。
DOI：
10.1016/s0016-5085(74)80038-7
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发表时间：
1974
期刊：
影响因子：
29.4
通讯作者：
S. Konturek
中科院分区：
文献类型：
--
作者：
M. Grossman;S. Konturek
在患有Heidenhain袋和主胃胃瘘管的狗中，静脉注射12 µmoles kg-1剂量的甲硫米特（一种H2阻断型组胺拮抗剂），可以抑制组胺、五肽胃蛋白酶、2-脱氧葡萄糖和食物（肝脏提取物）刺激期间的胃酸分泌。硫酸阿托品（0.14 μmole kg-1，静脉注射）也可抑制对除组胺外的所有这些兴奋剂的反应。为了解释这些发现，我们推测壁细胞上组胺、胃泌素和乙酰胆碱的受体相互作用。
In dogs with Heidenhain pouches and gastric fistulae of the main stomach, metiamide, a histamine antagonist of the H2-blocking variety, in a dose of 12 µmoles kg-1intravenously, inhibited gastric acid secretion during stimulation by histamine, pentagastrin, 2-deoxyglucose, and food (liver extract). Atropine sulfate (0.14 µmole kg-1intravenously) also inhibited the response to all of these stimulants except histamine. To account for these findings, we speculate that the receptors on the parietal cell for histamine, gastrin, and acetylcholine interact.