Imidazole modified Pt(iv) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance
Imidazole modified Pt(iv) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance
复制标题
咪唑修饰的负载 Pt(iv) 前药的多级 pH 响应纳米颗粒可克服顺铂耐药性
DOI：
10.1039/d0cc01846e
复制
发表时间：
2020-09-28
影响因子：
4.9
通讯作者：
Yu, Changyuan
中科院分区：
文献类型：
--
作者：
Kang, Xiaoxu;Wang, Yushu;Yu, Changyuan
具有长脂质尾的咪唑修饰的 Pt(iv) 前药可以通过与带负电的亲水聚合物静电络合组装成多级 pH 响应纳米颗粒。该策略可以显着克服顺铂耐药性。
An imidazole modified Pt(iv) prodrug with a long lipid tail can assemble into multi-stage pH responsive nanoparticlesviaelectrostatic complexation with a negatively charged hydrophilic polymer. This strategy could overcome cisplatin resistance significantly.