A randomized controlled trial of lorcaserin and lifestyle counselling for weight loss maintenance: changes in emotion- and stress-related eating, food cravings and appetite.
A randomized controlled trial of lorcaserin and lifestyle counselling for weight loss maintenance: changes in emotion- and stress-related eating, food cravings and appetite.
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DOI：
10.1111/cob.12279
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发表时间：
2018-12
期刊：
影响因子：
3.3
通讯作者：
Tronieri JS
中科院分区：
文献类型：
--
作者：
Chao AM;Wadden TA;Pearl RL;Alamuddin N;Leonard SM;Bakizada ZM;Pinkasavage E;Gruber KA;Walsh OA;Berkowitz RI;Alfaris N;Tronieri JS
抗肥胖药物可以帮助人们维持饮食引起的食欲下降。本探索性分析评估了氯卡色林对随机化后24周情绪和压力相关进食、食物渴望和其他食欲指标（即，暴饮暴食、认知抑制、去抑制、饥饿、对进食的专注和饱腹感）。母研究在137名成人（平均年龄=46.1岁，86.1%为女性，68.6%为黑人）中调查了氯卡色林联合行为治疗在促进维持减肥方面的疗效，这些成人在14周低热量饮食（LCD）导入期间体重减轻≥5%。参与者被随机分配到氯卡色林或安慰剂组，并提供小组减肥维持咨询会议。在LCD开始（第-14周）、随机化（0）和第24周测量情绪和压力相关的进食、食物渴望和食欲。从随机分组开始，与安慰剂治疗的参与者相比，氯卡色林治疗的参与者在情绪和压力相关饮食方面有显著更大的改善（p=0.04）。然而，在随机分组后，各组在食欲、暴饮暴食或其他食欲指标的频率变化方面没有显著差异（ps>0.05）。与安慰剂相比，氯卡色林可能会改善情绪和压力相关的饮食。
Antiobesity medication may help people maintain diet-induced reductions in appetite. The present exploratory analysis assessed the effects of lorcaserin on changes at 24 weeks post-randomization in emotion- and stress-related eating, food cravings, and other measures of appetite (i.e., binge eating, cognitive restraint, disinhibition, hunger, preoccupation with eating, and fullness). The parent study investigated the efficacy of combined lorcaserin and behavioral treatment in facilitating weight loss maintenance in 137 adults (mean age=46.1 years, 86.1% female, 68.6% black) who had lost ≥5% of initial weight during a 14-week, low-calorie diet (LCD) run-in. Participants were randomly assigned to lorcaserin or placebo and provided group weight loss maintenance counseling sessions. Emotion- and stress-related eating, food cravings, and appetite were measured at the start of the LCD (week −14), randomization (0), and week 24. From randomization, lorcaserin-treated participants had significantly greater improvements in emotion- and stress-related eating compared to placebo-treated participants (p=0.04). Groups, however, did not differ significantly after randomization in changes in the frequency of food cravings, binge eating, or other measures of appetite (ps>0.05). Compared to placebo, lorcaserin may improve emotion- and stress-related eating.