Permeating the blood brain barrier and abrogating the inflammation in stroke: implications for stroke therapy.
Permeating the blood brain barrier and abrogating the inflammation in stroke: implications for stroke therapy.
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DOI：
10.2174/138161212802002841
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发表时间：
2012-07
影响因子：
3.1
通讯作者：
C. Borlongan;Loren E. Glover;P. Sanberg;D. Hess
中科院分区：
文献类型：
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作者：
C. Borlongan;Loren E. Glover;P. Sanberg;D. Hess
细胞疗法已被证明是治疗中风和其他神经疾病的一种潜在疗法。人脐血(HUCB)可能是一种有希望的干细胞来源，用于细胞治疗。当干细胞穿过血脑屏障(BBB)并最终到达受损的脑部位时，最理想的结果就会发生。根据我们之前的研究，我们认为甘露醇能够破坏血脑屏障，使移植的细胞从外周进入大脑。然而，当血脑屏障受损时，来自循环的炎症反应也可能穿透大脑，因此实际上可能会加剧中风，而不是提供治疗效果。我们讨论了核因子-kB诱饵如何抑制中风脑中的炎症反应，从而减少与血脑屏障中断相关的负面影响。在这篇综述中，我们建议将甘露醇诱导的血脑屏障渗透和核因子-kB诱骗结合起来，以提高细胞治疗在卒中中的疗效。
Cell therapy has been shown as a potential treatment for stroke and other neurological disorders. Human umbilical cord blood (HUCB) may be a promising source of stem cells for cell therapy. The most desired outcomes occur when stem cells cross the blood brain barrier (BBB) and eventually reach the injured brain site. We propose, from our previous studies, that mannitol is capable of disrupting the BBB, allowing the transplanted cells to enter the brain from the periphery. However, when the BBB is compromised, the inflammatory response from circulation may also be able to penetrate the brain and thus may actually exacerbate the stroke rather than afford therapeutic effects. We discuss how an NF-kB decoy can inhibit the inflammatory responses in the stroke brain thereby reducing the negative effects associated with BBB disruption. In this review, we propose the combination of mannitol-induced BBB permeation and NF-kB decoy for enhancing the therapeutic benefits of cell therapy in stroke.