Current use of selective serotonin reuptake inhibitors and risk of acute myocardial infarction
Current use of selective serotonin reuptake inhibitors and risk of acute myocardial infarction
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DOI：
10.2165/00002018-200427140-00006
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发表时间：
2004-01-01
期刊：
影响因子：
4.2
通讯作者：
Meier, CR
中科院分区：
文献类型：
--
作者：
Schlienger, RG;Fischer, LM;Meier, CR
背景资料：有研究表明，血小板活化增加会增加抑郁症患者发生急性心肌梗死（AMI）的风险。选择性5-羟色胺再摄取抑制剂（SSRIs）可通过血小板中5-羟色胺耗竭来减弱血小板活化。观察性研究表明，与使用SSRIs.Objective：本研究的目的是评估暴露于不同组别的抗抑郁药，包括SSRIs，和AMI的风险的关联AMI风险的不一致的结果。该研究还更详细地评估了一般成年人群中暴露于抗抑郁药的时间的影响（
Background: It has been suggested that increased platelet activation increases the risk of acute myocardial infarction (AMI) in patients with depression. Selective serotonin reuptake inhibitors (SSRIs) may attenuate platelet activation by serotonin depletion in platelets. Observational studies have shown discrepant results of AMI risk associated with the use of SSRIs.Objective: The aim of this study was to evaluate the association of exposure to different groups of antidepressants, including SSRIs, and the risk of AMI. The study also assessed in more detail the influence of timing of the exposure to antidepressants in a general adult population (