The effect of Functional Electrical Stimulation-assisted posture-shifting in bone mineral density: case series-pilot study.
The effect of Functional Electrical Stimulation-assisted posture-shifting in bone mineral density: case series-pilot study.
复制标题
DOI：
10.1038/s41394-022-00523-9
复制
发表时间：
2022-06-10
影响因子：
1.2
通讯作者：
Holderbaum, William
中科院分区：
文献类型：
--
作者：
Armengol, Monica;Zoulias, Ioannis D;Gibbons, Robin S;McCarthy, Ian;Andrews, Brian J;Harwin, William S;Holderbaum, William
一项在T2至T10完全性脊髓损伤（SCI）患者中使用站立动态负荷转移功能性电刺激（FES）的训练干预研究。研究FES辅助动态负荷转移运动对骨密度（BMD）的影响。本研究招募了12名患有ASIA A SCI的参与者。3名受试者完成了29 ± 5周的侧-侧负荷转移FES辅助运动，每周2次，持续1 h，并在隔天进行FES膝关节伸展运动，每周3次，持续1 h。在干预研究之前和之后，使用外周定量计算机断层扫描（pQCT）评估股骨远端和胫骨的体积骨矿物质密度（vBMD）。急性和亚急性SCI患者胫骨近端（平均26.9%）和远端（平均22.35%）的骨小梁vBMD（vBMDTRAB）绝对增加。观察到股骨远端vBMDTRAB丢失。在急性和亚急性SCI参与者中发现胫骨远端的vBMDTRAB改善，在急性参与者的胫骨近端，当进行29 ± 5周的反重力FES辅助承重运动时。如预期，在任何参与者中均未观察到股骨远端或胫骨干的vBMD改善。然而，在两名参与者中观察到胫骨近端和远端的vBMD改善。这项研究提供了证据表明，当高强度运动与低强度运动相结合时，vBMDTRAB改善，每周5次，持续1小时。
A training intervention study using standing dynamic load-shifting Functional Electrical Stimulation (FES) in a group of individuals with complete spinal cord injury (SCI) T2 to T10. Investigate the effect of FES-assisted dynamic load-shifting exercises on bone mineral density (BMD). University Lab within the Biomedical Engineering Twelve participants with ASIA A SCI were recruited for this study. Three participants completed side-to-side load-shifting FES-assisted exercises for 29 ± 5 weeks, 2× per week for 1 h, and FES knee extension exercises on alternate days 3× per week for 1 h. Volumetric Bone Mineral density (vBMD) at the distal femur and tibia were assessed using peripheral quantitative computed tomography (pQCT) before and after the intervention study. Participants with acute and subacute SCI showed an absolute increase of f trabecular vBMD (vBMDTRAB) in the proximal (mean of 26.9%) and distal tibia (mean of 22.35%). Loss of vBMDTRAB in the distal femur was observed. Improvements in vBMDTRAB in the distal tibia were found in acute and subacute SCI participants, and in the proximal tibia of acute participants, when subjected to anti-gravity FES-assisted load-bearing exercises for 29 ± 5 weeks. No vBMD improvement in distal femur or tibial shaft were observed in any of the participants as was expected. However, improvements of vBMD in the proximal and distal tibia were observed in two participants. This study provides evidence of an improvement of vBMDTRAB, when combining high-intensity exercises with lower intensity exercises 5× per week for 1 h.