Predicting intention to biobank: a national survey
Predicting intention to biobank: a national survey
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DOI：
10.1093/eurpub/ckq136
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发表时间：
2012-02-01
影响因子：
4.4
通讯作者：
Stranger, Mark J. A.
中科院分区：
文献类型：
--
作者：
Critchley, Christine R.;Nicol, Dianne;Stranger, Mark J. A.
背景：人口生物库的成功取决于公众的参与意愿。这项研究的目的是确定那些重要的因素，在确定公众的意图捐赠生物样本到一个公共资助的生物库，并允许该样本与医疗记录。方法：1000名澳大利亚人的全国样本进行了调查，通过电话采访。问题包括受访者参与生物库研究的可能性，对生物库的信任度，生物库研究将改善医疗保健的信念，以及对采血和DNA分析的总体满意度。结果如下：样本报告了对大学生物库的高度信任，坚信生物库研究将改善医疗保健，并强烈愿意参与生物库研究。使用结构方程模型，对生物库的信任被认为是参与生物库研究的意图的最重要的决定因素，其次是对采血和DNA分析的总体舒适度，对医疗保健福利和高等教育的信念。性别、年龄、父母身份和遗传条件的经验与参与意愿没有显著相关。结论：澳大利亚人普遍愿意参与生物库研究，这是由信任强烈决定的。虽然受益信念和研究的舒适度也是相关的，但无论这些因素如何，更高的信任与意图相关，这表明除了对改善医疗保健的关注之外，其他原因在确定公众参与生物库研究的意愿方面也很重要。
Background: The success of human population biobanks are dependent on the publics' willingness to participate. This research aimed to determine those factors important in determining the public's intention to donate a biological sample to a publicly funded biobank, and allow that sample to be linked with medical records. Methods: A national sample of 1000 Australians was surveyed via telephonic interviews. Questions included the reported likelihood that respondents would participate in biobank research, ratings of trust in biobanks, beliefs that biobank research will lead to improved health care and general ratings of comfort with blood taking and DNA analysis. Results: The sample reported a high level of trust in university biobanks, a strong belief that biobank research will lead to improved health care and a strong willingness to participate in biobank research. Using structural equation modelling, trust in the biobank was found to be the most important determinant of intention to participate in biobank research, followed by general comfort with blood taking and DNA analysis, belief in health-care benefits and higher education. Gender, age, parental status and experience of genetic conditions were not significantly associated with intention to participate. Conclusions: Australians are generally willing to participate in biobank research, and this is strongly determined by trust. While benefit beliefs and comfort with research are also relevant, higher trust was associated with intention regardless of these factors, suggesting reasons other than concern for improved health care are important in determining the publics' willingness to participate in biobank research.