High b value DWI in evaluation of the hyperacute cerebral ischemia at 3T: A comparative study in an embolic canine stroke model.
High b value DWI in evaluation of the hyperacute cerebral ischemia at 3T: A comparative study in an embolic canine stroke model.
复制标题
高 b 值 DWI 评估 3T 超急性脑缺血：栓塞犬卒中模型的比较研究。
DOI：
10.3892/etm.2016.3403
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发表时间：
2016-08
影响因子：
2.7
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Cheng Q;Xu X;Zu Q;Lu S;Yu J;Liu X;Wang B;Shi H;Teng G;Liu S
以往的研究表明，相对弥散加权成像（rDWI）信号强度的时间变化可能有助于确定中风的发病时间。此外，一些研究表明，与标准B值DWI相比，高B值DWI可提高超急性缺血性病变的检出率。然而，高B值DWI上rDWI的时间变化仍不清楚。因此，基于我们的栓塞性犬卒中模型，我们评估了高B值DWI上rDWI的时间演变，并进一步比较了其在预测缺血性卒中发作时间方面与标准B值DWI上rDWI的诊断价值。建立12只犬MCAO模型，分别于MCAO后1、2、3、4、5、6 h行DWI检查，B值分别为1,000、2,000、3000。高B值DWI在1 h后检测到所有缺血性病变，而标准B值DWI在1 h后未检测到1只犬的缺血性病变。在测试的所有三个B值下，rDWI在6 h内持续增加，而相对表观扩散系数（rADC）值在1h内迅速下降，然后变得相对稳定。B值为1,000、2,000和3,000时，rDWI预测3 h内缺血性病变的曲线下面积分别为0.897、0.929和0.938，rADC值分别为0.645、0.583和0.599。因此，结果表明，rDWI有助于老年超急性缺血性脑卒中，而rADC似乎不是。高B值DWI对缺血性病变的检出率更高，在判断超急性期脑卒中的发病时间方面具有更好的预测功效。
Previous studies have indicated that the temporal change of relative diffusion weighted imaging (rDWI) signal intensity may help to determine the onset time of a stroke. Furthermore, several studies have indicated that high b value DWI offered improved detection rates for hyper-acute ischemic lesions compared with standard b value DWI. However, the temporal changes of the rDWI on high b value DWI remain unclear. Therefore, based on our embolic canine stroke model, we evaluated the temporal evolution of rDWI on high b value DWI, and further compared its diagnostic value in predicting the onset time of ischemic stroke with rDWI on standard b value DWI. Twelve canine MCAO models were established, and DWI was performed at 1, 2, 3, 4, 5 and 6 h after MCAO, with 3 b values of 1,000, 2,000 and 3,000. High b value DWI detected all ischemic lesions after 1 h, while standard b value did not detect the ischemic lesions in one dog at 1 h. With all three of the tested b values, rDWIs increased continuously within 6 h, while relative apparent diffusion coefficient (rADC) values rapidly decreased in 1 h, then became relatively stable. The area under the curve values for rDWI with b value of 1,000, 2,000 and 3,000, in predicting ischemic lesions within 3 h were 0.897, 0.929 and 0.938, while for rADC were 0.645, 0.583 and 0.599, respectively. Therefore, the results indicated that the rDWI was helpful in aging hyper-acute ischemic stroke, while rADC appeared not to be. High b value DWI had a higher detection rate for ischemic lesions and better predictive efficacy in determining the onset time of hyper-acute stroke.