Alcohol and HBV synergistically promote hepatic steatosis
Alcohol and HBV synergistically promote hepatic steatosis
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酒精和乙型肝炎病毒协同促进肝脂肪变性
DOI：
10.1016/j.aohep.2019.04.013
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发表时间：
2019-11-01
影响因子：
3.8
通讯作者：
Wang, Li-Shun
中科院分区：
文献类型：
--
作者：
Li, Zhan-Ming;Kong, Chao-Yue;Wang, Li-Shun
背景与目的：肝炎病毒和酒精是导致肝损害的主要因素。B型肝炎病毒（HBV）和酒精在促进肝细胞损伤和疾病进展方面的协同作用已有报道。然而，HBV和乙醇在肝脂肪变性development.Methods的相互作用还没有完全阐明：8周龄的雄性C57 BL/6小鼠进行了治疗或不治疗HBV，乙醇，或HBV和乙醇（HBV +乙醇）的组合，随后由一个为期三周的高脂肪饮食（HFD）方案。分析肝组织学、血清生物标志物和肝甘油三酯水平。此外，酒精和HBV对肝脂肪变性的影响的荟萃分析population.Results：肝脂肪变性是HBV +乙醇组比其他组显着更严重。HBV + EtOH组血清丙氨酸氨基转移酶、天冬氨酸氨基转移酶和肝脏甘油三酯水平也显著高于其他组。HBV +EtOH组的HBeAg和HBsAg水平显著高于配对喂养的HBV感染小鼠。Meta分析结果显示，饮酒可使HBV感染者发生肝脂肪变性的风险增加43%（合并风险比（RR）= 1.43，1.3 < 0.01）。此外，饮酒会增加HBV感染患者发生肝脂肪变性的风险。(C)2019年丰达西翁临床医学协会由Elsevier Espana出版，S.L.U.
Background and aims: Hepatitis virus and alcohol are the main factors leading to liver damage. Synergy between hepatitis B virus (HBV) and alcohol in promoting liver cell damage and disease progression has been reported. However, the interaction of HBV and ethanol in hepatic steatosis development has not been fully elucidated.Methods: Eight-week-old male C57BL/6 mice were treated with or without HBV, ethanol, or the combination of HBV and ethanol (HBV +EtOH), followed by a three-week high-fat diet (HFD) regimen. Liver histology, serum biomarkers, and liver triglyceride levels were analysed. Furthermore, a meta-analysis of the effects of alcohol and HBV on hepatic steatosis in populations was performed.Results: Hepatic steatosis was significantly more severe in the HBV + EtOH group than in the other groups. The serum alanine aminotransferase, aspartate aminotransferase and liver triglyceride levels in the HBV + EtOH group were also significantly higher than those in the other groups. The HBeAg and HBsAg levels in the HBV +EtOH group were significantly higher than those in the pair-fed HBV-infected mice. In addition, the meta-analysis showed that alcohol consumption increased the risk of hepatic steatosis by 43% in HBV-infected patients (pooled risk ratio (RR) = 1.43, 1 3 < 0.01).Conclusions: Alcohol and HBV synergistically promote high-fat diet-induced hepatic steatosis in mice. In addition, alcohol consumption increases the risk of hepatic steatosis in HBV-infected patients. (C) 2019 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U.