The promising impact of molecular profiling on treatment strategies in oral cancers
The promising impact of molecular profiling on treatment strategies in oral cancers
复制标题
DOI：
10.1016/j.jormas.2017.05.004
复制
发表时间：
2017-09-01
影响因子：
2.2
通讯作者：
Bertolus, C.
中科院分区：
文献类型：
--
作者：
Foy, J. -P.;Saintigny, P.;Bertolus, C.
口腔鳞状细胞癌（OSCC）是癌症相关发病率和死亡率的主要原因。虽然OSCC可能从容易获得的口腔肿瘤前病变（opl）发展而来，但迄今为止还没有关于降低恶性转化率的干预措施的报道。口腔癌变的综合分子特征可能有助于改进opl和OSCC患者的治疗策略。在此，我们回顾了口腔癌变过程中不同阶段发生的主要分子改变，并展示了基于分子的药物和手术如何影响未来OSCC的结果。(C) 2017 Elsevier Masson SAS。版权所有。
Oral squamous cell carcinoma (OSCC) is a major cause of cancer-associated morbidity and mortality. Although OSCC may develop from easily accessible oral preneoplastic lesions (OPLs), no intervention has been reported so far that reduces the rate of malignant transformation. A comprehensive molecular characterization of oral carcinogenesis may help refining treatment strategies both in patients with OPLs and OSCC. Herein, we review main molecular alterations occurring at different steps during oral carcinogenesis and show how molecularly-based medicine and surgery may impact the outcome of OSCC in the future. (C) 2017 Elsevier Masson SAS. All rights reserved.