Antimicrobial and Cell-Penetrating Peptides: Understanding Penetration for the Design of Novel Conjugate Antibiotics.
Antimicrobial and Cell-Penetrating Peptides: Understanding Penetration for the Design of Novel Conjugate Antibiotics.
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DOI：
10.3390/antibiotics11111636
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发表时间：
2022-11-16
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影响因子：
--
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抗菌肽是一类能穿透细菌内外膜的短小分子多肽。它们与细胞穿透肽(CPPs)一起被称为膜活性多肽，是一种可以跨生物膜转运的多肽。在过去的五十年里，人们试图了解驱动膜与膜活性多肽相互作用的分子特征。本文综述了这些多肽用于转运的膜的特性，以及对转运具有重要作用的膜活性多肽的物理化学特性。此外，它还提供了近年来如何利用这些特征来创建由膜活性多肽组成的结合物的例子，该结合物被称为“载体”，附着在当前或新的抗生素上，称为“货物”或“有效载荷”。此外，随着抗菌素耐药性问题的日益加剧，需要采用新的策略来对抗这一全球公共卫生威胁，综述还讨论了哪些特性可能有助于形成能够通过细菌外膜运送货物的理想多肽载体。
Antimicrobial peptides (AMPs) are short oligopeptides that can penetrate the bacterial inner and outer membranes. Together with cell-penetrating peptides (CPPs), they are called membrane active peptides; peptides which can translocate across biological membranes. Over the last fifty years, attempts have been made to understand the molecular features that drive the interactions of membranes with membrane active peptides. This review examines the features of a membrane these peptides exploit for translocation, as well as the physicochemical characteristics of membrane active peptides which are important for translocation. Moreover, it presents examples of how these features have been used in recent years to create conjugates consisting of a membrane active peptide, called a “vector”, attached to either a current or novel antibiotic, called a “cargo” or “payload”. In addition, the review discusses what properties may contribute to an ideal peptide vector able to deliver cargoes across the bacterial outer membrane as the rising issue of antimicrobial resistance demands new strategies to be employed to combat this global public health threat.
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影响因子：
4.9
作者：
Defraine, Valerie;Schuermans, Joris;Briers, Yves
通讯作者：
Briers, Yves
影响因子：
5.3
作者：
Dhanda, Geetika;Mukherjee, Riya;Haldar, Jayanta
通讯作者：
Haldar, Jayanta
影响因子：
4.8
作者：
Derossi, D;Calvet, S;Prochiantz, A
通讯作者：
Prochiantz, A
DOI：
10.1034/j.1399-3011.1999.00055.x
发表时间：
1999-05-01
期刊：
JOURNAL OF PEPTIDE RESEARCH
影响因子：
--
作者：
Bogdanowich-Knipp, SJ;Jois, DSS;Siahaan, TJ
通讯作者：
Siahaan, TJ
影响因子：
5.5
作者：
Avci FG;Akbulut BS;Ozkirimli E
通讯作者：
Ozkirimli E