Multiple Sclerosis and the Choroid Plexus: Emerging Concepts of Disease Immunopathophysiology
Multiple Sclerosis and the Choroid Plexus: Emerging Concepts of Disease Immunopathophysiology
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DOI：
10.1016/j.pediatrneurol.2019.08.007
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发表时间：
2020-02-01
影响因子：
3.8
通讯作者：
Perez, Carlos A.
中科院分区：
文献类型：
--
作者：
Dixon, Grant A.;Perez, Carlos A.
背景：多发性硬化症和颅内肿瘤并存是非常罕见的，这种情况是否可以用因果关系或巧合来解释仍然是一个有争议的问题。脉络丛可能是肿瘤细胞侵袭和淋巴细胞侵入中枢神经系统的场所。方法：我们描述了一位13岁的男孩并发多发性硬化症和脉络丛乳头状瘤，然后回顾已发表的文献，重点是多发性硬化症的神经炎症的病理生理学机制以及脉络丛在这一过程中的潜在作用。结果：越来越多的证据表明，脉络丛的生理和功能失调可能是中枢神经系统炎症的常见病理生理机制。结论：在多发性硬化症中，脉络丛可能是导致中枢神经系统炎症的一种常见的病理生理机制。脉络丛在早期可作为淋巴细胞从外周血进入中枢神经系统的通道。然而，还需要进一步的研究来确定脉络丛的结构变化是否在多发性硬化症的病理生理学中起作用，并提供合适的模型来确定其后果。(C)2019 Elsevier Inc.保留所有权利。
Background: The coexistence of multiple sclerosis and intracranial neoplasms is very rare, and whether this occurrence can be explained by a causal relationship or by coincidence remains a matter of debate. Possible roles of the choroid plexus as a site of tumor cell invasion and lymphocyte infiltration into the central nervous system have been hypothesized in recent studies.Methods: We describe a 13-year-old boy with concurrent multiple sclerosis and choroid plexus papilloma, then review the published literature with a focus on the pathophysiologic mechanisms of neuroinflammation in multiple sclerosis and the potential role of the choroid plexus in this process.Results: A growing body of evidence suggests that both physical and functional dysregulation of the choroid plexus may be a common mechanism underlying the pathophysiology of central nervous system inflammation.Conclusions: In multiple sclerosis, the choroid plexus could act as a gateway for lymphocyte entry from the peripheral blood into the central nervous system at its earlier stages. However, future studies are needed to identify whether structural alterations of the choroid plexus play a role in the pathophysiology of multiple sclerosis and to provide suitable models to determine their consequences. (C) 2019 Elsevier Inc. All rights reserved.