The gut barrier and chronic diseases.
The gut barrier and chronic diseases.
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DOI：
10.1097/mco.0000000000000820
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发表时间：
2022-05-01
影响因子：
3.1
通讯作者：
Cresci, Gail A. M.
中科院分区：
文献类型：
--
作者：
Santilli, Anthony;Stefanopoulos, Stavros;Cresci, Gail A. M.
本综述的目的是提供关于肠道屏障及其与慢性疾病的关系的最新信息，并回顾用于识别肠道屏障完整性的生物标志物。这篇综述是及时和相关的，因为我们对肠道微生物组和肠道屏障在健康和疾病中的作用的了解正在增加。本综述概述了：肠道屏障，这是复杂的，由粘液层和肠道顶端连接蛋白复合物组成;肠道微生物组与调节肠道屏障完整性的关系;选择已知与肠道生态失调和肠道完整性受损或“漏肠”相关的急性和慢性疾病;以及目前用于识别肠道屏障完整性丧失的方法。许多慢性疾病与肠道生态失调和全身炎症有关。确定肠道屏障是否在这些条件下受到损害，可以帮助告知潜在的治疗方法，作为纠正肠道屏障完整性损失和减轻相关医疗状况的手段。
The purpose of this review is to provide an update regarding the gut barrier and its involvement with chronic diseases, as well as to review biomarkers for identification of gut barrier integrity. This review is timely and relevant as our knowledge is increasing regarding the role of the gut microbiome and the gut barrier in health and disease. This review provides an overview of: the gut barrier, which is complex and comprised of the mucus layer and the intestinal apical junctional protein complex; the gut microbiome in its relation to regulating the integrity of the gut barrier; select acute and chronic conditions that are known to be associated with gut dysbiosis and impaired gut integrity or “leaky gut”; and current means for identifying loss in gut barrier integrity. Many chronic conditions are associated with gut dysbiosis and systemic inflammation. Identifying whether the gut barrier is compromised in these conditions could help to inform potential therapeutics as a means to correct losses in gut barrier integrity and mitigate associated medical conditions.