Recruitment of brown adipose tissue as a therapy for obesity-associated diseases.
Recruitment of brown adipose tissue as a therapy for obesity-associated diseases.
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DOI：
10.3389/fendo.2012.00014
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发表时间：
2012
影响因子：
5.2
通讯作者：
Farmer SR
中科院分区：
文献类型：
--
作者：
Boss O;Farmer SR
棕色脂肪组织（BAT）在动物冷诱导的非颤抖性产热（CIT，NST）和体重动态平衡中起着关键作用。BAT是一种灵活的组织，可以通过刺激（包括动物中的小分子）招募，并在没有刺激的情况下萎缩。事实上，BAT（和UCP 1）对动物（啮齿动物）的静息代谢率和健康体重稳态的贡献现在已经得到了很好的证实。许多研究表明，在各种啮齿动物模型中对肥胖和相关疾病的抵抗是由于BAT质量和棕色脂肪细胞或UCP 1表达的数量增加。最近在成年人中发现的活性BAT重新点燃了BAT是对抗肥胖相关代谢紊乱的治疗靶点的概念。在这篇综述中，我们强调在啮齿动物中进行的调查，支持在肥胖个体中激活BAT形成和/或功能的论点。我们还提出，增强白色脂肪组织（WAT）中棕色脂肪细胞的功能也将调节能量平衡，并降低WAT中肥胖相关炎症中的胰岛素抵抗。
Brown adipose tissue (BAT) has been recognized for more than 20 years to play a key role in cold-induced non-shivering thermogenesis (CIT, NST), and body weight homeostasis in animals. BAT is a flexible tissue that can be recruited by stimuli (including small molecules in animals), and atrophies in the absence of a stimulus. In fact, the contribution of BAT (and UCP1) to resting metabolic rate and healthy body weight homeostasis in animals (rodents) is now well established. Many investigations have shown that resistance to obesity and associated disorders in various rodent models is due to increased BAT mass and the number of brown adipocytes or UCP1 expression in various depots. The recent discovery of active BAT in adult humans has rekindled the notion that BAT is a therapeutic target for combating obesity-related metabolic disorders. In this review, we highlight investigations performed in rodents that support the contention that activation of BAT formation and/or function in obese individuals is therapeutically powerful. We also propose that enhancement of brown adipocyte functions in white adipose tissue (WAT) will also regulate energy balance as well as reduce insulin resistance in obesity-associated inflammation in WAT.