Prostaglandin‐Independent Stimulation of Interleukin‐6 Production by Fibrinogen Degradation Product D in Perfused Murine Liver
Prostaglandin‐Independent Stimulation of Interleukin‐6 Production by Fibrinogen Degradation Product D in Perfused Murine Liver
复制标题
灌注小鼠肝脏中纤维蛋白原降解产物 D 不依赖前列腺素刺激白细胞介素 6 的产生
DOI：
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发表时间：
1998
影响因子：
3.7
通讯作者：
Mandl
中科院分区：
文献类型：
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作者：
Csala;Léránt;Bánhegyi;Kardon;Puskás;Mucha;Machovich;Falus;Mandl
细菌内毒素（LPS）和纤维蛋白原降解产物D（FDP-D）都是肝脏产生白细胞介素-6（IL-6）的强效刺激物，但它们的代谢作用存在差异。本研究的目的是在灌注的小鼠肝脏中比较洋地黄素在LPS或FDP-D增强IL-6产生中的作用。吲哚美辛显著抑制LPS的作用，但在FDP-D的情况下无效。因此，在添加FDP-D后，胡枝子素D2和E2的产生没有升高，而它们的形成被LPS增加了数倍。同时，在加入FDP‐D后，灌注肝脏中的白细胞介素1（IL‐1）产量显著升高。这表明，野牡丹素不参与FDP‐D对肝脏的影响。FDP-P对IL-6产生的刺激作用可能是IL-1水平升高的结果。
Bacterial endotoxin (LPS) and fibrinogen degradation product D (FDP‐D) are both potent stimulators of interleukin‐6 (IL‐6) production in liver, however, there are differences in their metabolic effects. The aim of the present study was to compare the role of prostaglandins in the enhancement of IL‐6 production by LPS or FDP‐D in perfused mouse livers. Indomethacin inhibited the effect of LPS significantly but was ineffective in the case of FDP‐D. Accordingly, production of prostaglandins D2 and E2 was not elevated following the addition of FDP‐D, while their formation was increased several fold by LPS. At the same time interleukin‐1 (IL‐1) production in perfused liver rose markedly upon the addition of FDP‐D. It is suggested that prostaglandins are not involved in the effects of FDP‐D on the liver. The stimulatory effect of FDP‐P on IL‐6 production might be the consequence of elevated IL‐1 levels.
影响因子：
15.9
作者：
Gabay, C;Smith, MF;Arend, WP
通讯作者：
Arend, WP