MyrSINEs: A novel SINE family in the anteater genomes
MyrSINEs: A novel SINE family in the anteater genomes
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DOI：
10.1016/j.gene.2007.06.003
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发表时间：
2007-10-01
期刊：
影响因子：
3.5
通讯作者：
Okada, Norihiro
中科院分区：
文献类型：
--
作者：
Nishihara, Hidenorl;Kuno, Shuichi;Okada, Norihiro
最近快速生成的基因组序列数据使许多研究人员能够在各种哺乳动物物种中进行比较分析。然而，转座因子的表征，如短穿插重复因子（sin），还没有在一些哺乳动物群体中报道。由于sin占据了哺乳动物基因组的很大一部分，它们被认为在进化过程中对宿主基因组的构成和多样化做出了贡献。在本研究中，我们在食蚁兽基因组中鉴定了一个新的SINE家族，并将其命名为myrsin家族。典型的正弦由一个trna相关区域、一个tna不相关区域和一个富含at（或多聚a）区域组成。myrsin只有trna相关和poly-A区域；它们属于一个叫做t- sin的群体。发现myrsin的tRNA相关区域来源于tRNA（Gly）。我们证明了myrsin家族可以分为三个亚家族。其中两个myrsin亚家族分布在巨食蚁兽和塔曼杜鹃的基因组中，而另一个则只存在于巨食蚁兽的基因组中。我们讨论了食蚁兽的进化历史及其与食蚁兽进化的关系。我们还推测t-正弦的简单结构可能是典型正弦结构产生的潜在进化来源。(c) 2007 Elsevier B.V.版权所有
Recent rapid generation of genomic sequence data has allowed many researchers to perform comparative analyses in various mammalian species. However, characterization of transposable elements, such as short interspersed repetitive elements (SINEs), has not been reported for several mammalian groups. Because SINEs occupy a large portion of the mammalian genome, they are believed to have contributed to the constitution and diversification of the host genomes during evolution. In the present study, we characterized a novel SINE family in the anteater genomes and designated it the MyrSINE family. Typical SINEs consist of a tRNA-related, a tNA-unrelated and an AT-rich (or poly-A) region. MyrSINEs have only tRNA-related and poly-A regions; they are included in a group called t-SINE. The tRNA-related regions of the MyrSINEs were found to be derived from tRNA(Gly). We demonstrate that the MyrSINE family can be classified into three subfamilies. Two of the MyrSINE subfamilies are distributed in the genomes of both giant anteater and tamandua, while the other is present only in the giant anteater. We discuss the evolutionary history of MyrSINEs and their relationship to the evolution of anteaters. We also speculate that the simple structure of t-SINEs may be a potential evolutionary source for the generation of the typical SINE structure. (c) 2007 Elsevier B.V. All rights reserved.