Defining treatment response and symptom remission for anxiety disorders in pediatric autism spectrum disorders using the Pediatric Anxiety Rating Scale.
Defining treatment response and symptom remission for anxiety disorders in pediatric autism spectrum disorders using the Pediatric Anxiety Rating Scale.
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DOI：
10.1007/s10803-015-2483-9
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发表时间：
2015-10
影响因子：
3.9
通讯作者：
Storch EA
中科院分区：
文献类型：
--
作者：
Johnco CJ;De Nadai AS;Lewin AB;Ehrenreich-May J;Wood JJ;Storch EA
本研究采用儿科焦虑评定量表（PARS），探讨了评估自闭症谱系障碍（ASD）青少年焦虑治疗反应和缓解的最佳指南。收集了108名7-16岁患有焦虑和ASD共病的儿童接受认知行为治疗前后的数据。使用信号检测分析，使用受试者工作特征方法评估PARS的最佳截止值。在PARS上症状减少15%时达到与缓解标准的最大一致性。与缓解标准的最大一致性是在症状减轻40%或治疗后评分为10分或更低时达到的。结果对研究试验和临床实践中使用的标准化标准有影响。
This study examined optimal guidelines to assess treatment response and remission for anxiety in youth with autism spectrum disorders (ASD) using the Pediatric Anxiety Rating Scale (PARS). Data was collected for 108 children aged 7–16 years with comorbid anxiety and ASD before and after receiving cognitive behavior therapy. Optimal cut-offs on the PARS were assessed using signal detection analyses using receiver operating characteristic methods. Maximum agreement with response criteria was achieved at 15% reduction in symptoms on the PARS. Maximum agreement with remission criteria was achieved at 40% reduction in symptoms, or at a score of 10 or below at post-treatment. Results have implications for standardizing criteria used in research trials and clinical practice.