Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women
Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women
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DOI：
10.1093/oxfordjournals.aje.a009781
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发表时间：
1999-01-15
影响因子：
5
通讯作者：
Folsom, AR
中科院分区：
文献类型：
--
作者：
Bostick, RM;Kushi, LH;Folsom, AR
为了研究更多地摄入钙、维生素D或奶制品是否可以预防缺血性心脏病死亡率，作者分析了一项前瞻性队列研究的数据，该研究包括34,486名绝经后爱荷华州55-69岁且无缺血性心脏病史的妇女，她们在1986年完成了一份饮食调查问卷。记录了387例缺血性心脏病死亡（国际疾病分类，第九次修订，编码410-414，429.2）。总钙、维生素D和奶制品摄入量最高四分位数与最低四分位数的多变量调整相对风险如下：0.67（95%置信区间（CI）0.47-0.94;趋势p = 0.09），钙，1.41（95% CI 0.93-2.15;趋势p = 0.12），乳制品为0.94（95% CI 0.66-1.35;趋势p = 0.68）。高膳食钙但不补充钙摄入的相对危险度为0.63（95%CI 0.40-0.98），高补充钙但低膳食钙摄入的相对危险度为0.66（95%CI 0.36-1.23）。这些结果表明，较高的钙摄入量，而不是维生素D或奶制品，与绝经后妇女缺血性心脏病死亡率的降低有关，无论是通过饮食，补充剂或两者兼而有之来获得较高的钙摄入量，都可以降低风险。
To investigate whether greater intakes of calcium, vitamin D, or milk products may protect against ischemic heart disease mortality, the authors analyzed data from a prospective cohort study of 34,486 postmenopausal Iowa women 55-69 years old and without a history of ischemic heart disease who completed a dietary questionnaire in 1986, Through 1994, 387 deaths due to ischemic heart disease were documented (International Classification of Diseases, Ninth Revision, codes 410-414, 429.2). The multivariate-adjusted relative risks for the highest versus the lowest quartiles of total calcium, vitamin D, and milk product intakes were as follows: 0.67 (95% confidence interval (CI) 0.47-0.94; p for trend = 0.09) for calcium, 1.41 (95% CI 0.93-2.15; p for trend = 0.12) for vitamin D, and 0.94 (95% CI 0.66-1.35; p for trend = 0.68) for milk products. The relative risk was 0.63 (95% CI 0.40-0.98) for high dietary calcium but no supplemental calcium intake and 0.66 (95% CI 0.36-1.23) for high supplemental calcium but low dietary calcium intake. These results suggest that a higher intake of calcium, but not of vitamin D or milk products, is associated with reduced ischemic heart disease mortality in postmenopausal women, and reduced risk may be achievable whether the higher intake of calcium is attained by diet, supplements, or both.